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The Complex Relationship between Diabetic Retinopathy and High-Mobility Group Box: A Review of Molecular Pathways and Therapeutic Strategies.
Antioxidants ( IF 7 ) Pub Date : 2020-07-26 , DOI: 10.3390/antiox9080666 Marcella Nebbioso 1 , Alessandro Lambiase 1 , Marta Armentano 1 , Giosuè Tucciarone 1 , Vincenza Bonfiglio 2 , Rocco Plateroti 1 , Ludovico Alisi 1
Antioxidants ( IF 7 ) Pub Date : 2020-07-26 , DOI: 10.3390/antiox9080666 Marcella Nebbioso 1 , Alessandro Lambiase 1 , Marta Armentano 1 , Giosuè Tucciarone 1 , Vincenza Bonfiglio 2 , Rocco Plateroti 1 , Ludovico Alisi 1
Affiliation
High-mobility group box 1 (HMGB1) is a protein that is part of a larger family of non-histone nuclear proteins. HMGB1 is a ubiquitary protein with different isoforms, linked to numerous physiological and pathological pathways. HMGB1 is involved in cytokine and chemokine release, leukocyte activation and migration, tumorigenesis, neoangiogenesis, and the activation of several inflammatory pathways. HMGB1 is, in fact, responsible for the trigger, among others, of nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), toll-like receptor-4 (TLR-4), and vascular endothelial growth factor (VEGF) pathways. Diabetic retinopathy (DR) is a common complication of diabetes mellitus (DM) that is rapidly growing in number. DR is an inflammatory disease caused by hyperglycemia, which determines the accumulation of oxidative stress and cell damage, which ultimately leads to hypoxia and neovascularization. Recent evidence has shown that hyperglycemia is responsible for the hyperexpression of HMGB1. This protein activates numerous pathways that cause the development of DR, and HMGB1 levels are constantly increased in diabetic retinas in both proliferative and non-proliferative stages of the disease. Several molecules, such as glycyrrhizin (GA), have proven effective in reducing diabetic damage to the retina through the inhibition of HMGB1. The main focus of this review is the growing amount of evidence linking HMGB1 and DR as well as the new therapeutic strategies involving this protein.
中文翻译:
糖尿病性视网膜病变与高活动性族之间的复杂关系:分子途径和治疗策略的综述。
高迁移率族盒1(HMGB1)是一种蛋白质,属于较大的非组蛋白核蛋白家族。HMGB1是具有不同同工型的泛在蛋白,与多种生理和病理途径相关。HMGB1参与细胞因子和趋化因子的释放,白细胞的激活和迁移,肿瘤发生,新血管生成以及几种炎症途径的激活。实际上,HMGB1负责触发核因子-κB(NF-κB),肿瘤坏死因子-α(TNF-α),toll样受体-4(TLR-4)和血管内皮生长因子(VEGF)通路。糖尿病性视网膜病(DR)是糖尿病(DM)的常见并发症,其数量迅速增加。DR是由高血糖症引起的炎性疾病,它决定了氧化应激和细胞损伤的积累,最终导致缺氧和新生血管形成。最近的证据表明,高血糖是HMGB1过度表达的原因。该蛋白激活导致DR发生的多种途径,并且在该疾病的增生和非增生阶段,糖尿病视网膜中HMGB1的水平不断增加。事实证明,诸如甘草甜素(GA)等几种分子可通过抑制HMGB1来有效减少糖尿病对视网膜的损害。这篇综述的主要重点是与HMGB1和DR相关的证据越来越多,以及涉及该蛋白的新治疗策略。该蛋白激活导致DR发生的多种途径,并且在该疾病的增生和非增生阶段,糖尿病视网膜中HMGB1的水平不断增加。事实证明,诸如甘草甜素(GA)等几种分子可通过抑制HMGB1来有效减少糖尿病对视网膜的损害。这篇综述的主要重点是与HMGB1和DR相关的证据越来越多,以及涉及该蛋白的新治疗策略。该蛋白激活导致DR发生的多种途径,并且在该疾病的增生和非增生阶段,糖尿病视网膜中HMGB1的水平不断增加。事实证明,诸如甘草甜素(GA)等几种分子可通过抑制HMGB1来有效减少糖尿病对视网膜的损害。这篇综述的主要重点是与HMGB1和DR相关的证据越来越多,以及涉及该蛋白的新治疗策略。
更新日期:2020-07-26
中文翻译:
糖尿病性视网膜病变与高活动性族之间的复杂关系:分子途径和治疗策略的综述。
高迁移率族盒1(HMGB1)是一种蛋白质,属于较大的非组蛋白核蛋白家族。HMGB1是具有不同同工型的泛在蛋白,与多种生理和病理途径相关。HMGB1参与细胞因子和趋化因子的释放,白细胞的激活和迁移,肿瘤发生,新血管生成以及几种炎症途径的激活。实际上,HMGB1负责触发核因子-κB(NF-κB),肿瘤坏死因子-α(TNF-α),toll样受体-4(TLR-4)和血管内皮生长因子(VEGF)通路。糖尿病性视网膜病(DR)是糖尿病(DM)的常见并发症,其数量迅速增加。DR是由高血糖症引起的炎性疾病,它决定了氧化应激和细胞损伤的积累,最终导致缺氧和新生血管形成。最近的证据表明,高血糖是HMGB1过度表达的原因。该蛋白激活导致DR发生的多种途径,并且在该疾病的增生和非增生阶段,糖尿病视网膜中HMGB1的水平不断增加。事实证明,诸如甘草甜素(GA)等几种分子可通过抑制HMGB1来有效减少糖尿病对视网膜的损害。这篇综述的主要重点是与HMGB1和DR相关的证据越来越多,以及涉及该蛋白的新治疗策略。该蛋白激活导致DR发生的多种途径,并且在该疾病的增生和非增生阶段,糖尿病视网膜中HMGB1的水平不断增加。事实证明,诸如甘草甜素(GA)等几种分子可通过抑制HMGB1来有效减少糖尿病对视网膜的损害。这篇综述的主要重点是与HMGB1和DR相关的证据越来越多,以及涉及该蛋白的新治疗策略。该蛋白激活导致DR发生的多种途径,并且在该疾病的增生和非增生阶段,糖尿病视网膜中HMGB1的水平不断增加。事实证明,诸如甘草甜素(GA)等几种分子可通过抑制HMGB1来有效减少糖尿病对视网膜的损害。这篇综述的主要重点是与HMGB1和DR相关的证据越来越多,以及涉及该蛋白的新治疗策略。