Oxidative stress plays an important role in the onset as well as the progression of inflammation. Without proper intervention, acute inflammation could progress to chronic inflammation, resulting in the development of inflammatory diseases. Antioxidants, such as polyphenols, have been known to possess anti-oxidative properties which promote redox homeostasis. This has encouraged research on polyphenols as potential therapeutics for inflammation through anti-oxidative and anti-inflammatory pathways. In this review, the ability of polyphenols to modulate the activation of major pathways of inflammation and oxidative stress, and their potential to regulate the activity of immune cells are examined. In addition, in this review, special emphasis has been placed on the effects of polyphenols on inflammation in the brain–liver–gut axis. The data derived from in vitro cell studies, animal models and human intervention studies are discussed.

中文翻译：

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多酚作为抗氧化剂和抗炎化合物在脑-肝-肠轴中的相互作用。

氧化应激在炎症的发生和发展中起重要作用。没有适当的干预，急性炎症可能会发展成慢性炎症，从而导致炎症性疾病的发展。已知多酚等抗氧化剂具有促进氧化还原稳态的抗氧化特性。这鼓励了对多酚作为通过抗氧化和消炎途径进行炎症治疗的潜在疗法的研究。在这篇综述中，研究了多酚调节炎症和氧化应激主要途径的激活的能力，以及调节免疫细胞活性的潜力。另外，在这篇综述中，特别强调了多酚对脑-肝-肠轴炎症的影响。