Human‐induced pluripotent stem cells (hiPSCs) are a promising cell source for treating ischaemic stroke. Although autologous hiPSCs provide the advantage of avoiding immune rejection, their practical limitations, such as substantial amount of time and costs to generate individual iPSC lines, have hampered their widespread application in clinical settings. In this study, we investigated the therapeutic potential of neural precursor cells derived from human HLA‐homozygous induced pluripotent stem cells (hiPSC‐NPCs) following intracerebral transplantation into a rodent model of middle cerebral artery occlusion (MCAo).

中文翻译：

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HLA 纯合人 iPSC 衍生神经前体的脑内移植可改善啮齿动物缺血性卒中模型的行为和病理缺陷

人类诱导的多能干细胞（hiPSCs）是治疗缺血性中风的有前途的细胞来源。尽管自体 hiPSC 具有避免免疫排斥的优势，但它们的实际局限性，例如生成单个 iPSC 系的大量时间和成本，阻碍了它们在临床环境中的广泛应用。在这项研究中，我们研究了来自人类 HLA 纯合诱导多能干细胞 (hiPSC-NPCs) 的神经前体细胞在脑内移植到大脑中动脉闭塞 (MCAo) 啮齿动物模型后的治疗潜力。