Indazole carboxamide synthetic cannabinoids, a prevalent class of recreational drugs, are a major clinical, forensic and public health challenge. One such compound, 5F‐ADB, has been implicated in fatalities worldwide. Understanding its metabolism and distribution facilitates the development of laboratory assays to substantiate its consumption. Synthetic cannabinoid metabolites have been extensively studied in urine; studies identifying metabolites in blood are limited and no data on the metabolic stability (half‐life, clearance and extraction ratio) of 5F‐ADB have been published prior to this report.

中文翻译：

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合成大麻素5F-ADB的代谢谱分析和通过人肝微粒体培养和超高效液相色谱/高分辨率质谱鉴定真实人血样品中的代谢物。

吲唑羧酰胺合成大麻素是一种流行的休闲药物，是临床，法医和公共卫生领域的主要挑战。其中一种化合物5F-ADB已与全世界的死亡人数有关。了解其代谢和分布有助于实验室测定法的发展，以证实其消耗量。合成大麻素代谢物已在尿液中进行了广泛研究。鉴定血液中代谢物的研究非常有限，在此报告之前，尚未发表有关5F-ADB的代谢稳定性（半衰期，清除率和提取率）的数据。