This study investigated the blood pressure (BP) lowering and cardioprotective effects of oat avenanthramide C and beta‐glucan alone or in combination in spontaneously hypertensive rats (SHR). Five‐weeks‐old male SHR and Wistar‐Kyoto rats received vehicle, avenanthramide C and beta‐glucan alone or a combination of avenanthramide C and beta‐glucan via gavage for 15 weeks. BP was measured at 0, 10, and 15 weeks of treatment. Echocardiography was performed at 15 weeks of treatment. Oxidative stress and inflammation were also measured. Beta‐glucan alone prevented the increase in systolic and diastolic BP in SHR, but avenanthramide C alone or the combination did not prevent the increase in systolic and diastolic BP. SHRs treated with beta‐glucan and not avenanthramide C or the combination reduced isovolumetric relaxation time when compared to SHR treated with vehicle. Beta‐glucan and avenanthramide C decreased the levels of malondialdehyde, a marker of oxidative stress in SHR. In conclusion, beta‐glucan is a potential antihypertensive agent that may alleviate cardiovascular abnormalities.

中文翻译：

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燕麦成分对自发性高血压大鼠血压的影响。

这项研究调查了燕麦自身高血压大鼠（SHR）单独或联合服用燕麦燕麦黄花酰胺C和β-葡聚糖的降血压（BP）和心脏保护作用。五周大的雄性SHR和Wistar-Kyoto大鼠通过管饲法分别接受了媒介物，金刚烷酰胺C和β-葡聚糖，或联合使用了金刚烷酰胺C和β-葡聚糖。在治疗0、10和15周时测量BP。在治疗15周时进行超声心动图检查。还测量了氧化应激和炎症。单独使用β-葡聚糖可以阻止SHR中收缩压和舒张压的升高，但是单独使用avenanthramide C或联合使用不能阻止收缩压和舒张压的升高。与用媒介物治疗的SHR相比，用β-葡聚糖而不是avenanthramide C治疗的SHR减少了等容松弛时间。β-葡聚糖和avenanthramide C降低了SHR中氧化应激的标志物丙二醛的水平。总之，β-葡聚糖是一种潜在的降压药，可缓解心血管异常。