The phosphoenolpyruvate-dependent glucose phosphotransferase system (PTSGlc) is the major uptake system responsible for transporting glucose, and is involved in glucose translocation and phosphorylation in Corynebacterium glutamicum. For the longest time, the PTSGlc was considered as the only uptake system for glucose. However, some PTS-independent glucose uptake systems (non-PTSGlc) were discovered in recent years, such as the coupling system of inositol permeases and glucokinases (IPGS) and the coupling system of β-glucoside-PTS permease and glucokinases (GPGS). The products (e.g. lysine, phenylalanine and leucine) will be increased because of the increasing intracellular level of phosphoenolpyruvate (PEP), while some by-products (e.g. lactic acid, alanine and acetic acid) will be reduced when this system become the main uptake pathway for glucose. In this review, we survey the uptake systems for glucose in C. glutamicum and their composition. Furthermore, we summarize the latest research of the regulatory mechanisms among these glucose uptake systems. Detailed strategies to manipulate glucose uptake system are addressed based on this knowledge.

中文翻译：

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谷氨酸棒杆菌的葡萄糖摄取系统：综述

磷酸烯醇丙酮酸依赖性葡萄糖磷酸转移酶系统 (PTSGlc) 是负责运输葡萄糖的主要摄取系统，并参与谷氨酸棒杆菌中的葡萄糖转运和磷酸化。长期以来，PTSGlc 被认为是唯一的葡萄糖摄取系统。然而，近年来发现了一些不依赖于 PTS 的葡萄糖摄取系统（non-PTSGlc），如肌醇渗透酶和葡萄糖激酶（IPGS）的偶联系统和β-葡萄糖苷-PTS 渗透酶和葡萄糖激酶的偶联系统（GPGS）。由于磷酸烯醇式丙酮酸 (PEP) 的细胞内水平增加，产物（例如赖氨酸、苯丙氨酸和亮氨酸）会增加，而一些副产物（例如乳酸、当该系统成为葡萄糖的主要摄取途径时，丙氨酸和乙酸）将被还原。在这篇综述中，我们调查了谷氨酸棒杆菌中葡萄糖的吸收系统及其组成。此外，我们总结了这些葡萄糖摄取系统之间调节机制的最新研究。操纵葡萄糖摄取系统的详细策略在此知识的基础上提出。