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Synovial Fluid Biomarkers in Knee Osteoarthritis: A Systematic Review and Quantitative Evaluation Using BIPEDs Criteria.
CARTILAGE ( IF 2.8 ) Pub Date : 2020-07-25 , DOI: 10.1177/1947603520942941
Angelo Boffa 1 , Giulia Merli 2 , Luca Andriolo 1 , Christian Lattermann 3 , Gian M Salzmann 4 , Giuseppe Filardo 2
Affiliation  

Objective

The aim of this systematic review was to analyze the evidence about the efficacy of the several synovial fluid (SF) biomarkers proposed for knee osteoarthritis (OA), categorizing them by both molecular characteristics and clinical use according to the BIPEDs criteria, to provide a comprehensive and structured overview of the current literature.

Design

A systematic review was performed in May 2020 on PubMed, Cochrane Library, and Embase databases about SF biomarkers in patients with knee OA. The search was limited to articles in the last 20 years on human studies, involving patients with knee OA, reporting SF biomarkers. The evidence for each selected SF biomarker was quantified according to the 6 categories of BIPEDs classification.

Results

A total of 159 articles were included in the qualitative data synthesis and 201 different SF biomarkers were identified. Among these, several were investigated multiple times in different articles, for a total of 373 analyses. The studies included 13,557 patients with knee OA. The most promising SF biomarkers were C4S, IL-6, IL-8, Leptin, MMP-1/3, TIMP-1, TNF-α, and VEGF. The “burden of disease” and “diagnostic” categories were the most represented with 132 and 106 different biomarkers, respectively.

Conclusions

The systematic review identified numerous SF biomarkers. However, despite the high number of studies on the plethora of identified molecules, the evidence about the efficacy of each biomarker is supported by limited and often conflicting findings. Further research efforts are needed to improve the understanding of SF biomarkers for a better management of patients with knee OA.



中文翻译:

膝关节骨性关节炎中的滑液生物标志物:使用 BIPED 标准的系统评价和定量评估。

客观的

本系统评价的目的是分析关于膝关节骨性关节炎 (OA) 提出的几种滑液 (SF) 生物标志物疗效的证据,根据 BIPEDs 标准按分子特征和临床用途对它们进行分类,以提供全面的和当前文献的结构化概述。

设计

2020 年 5 月,对 PubMed、Cochrane 图书馆和 Embase 数据库进行了关于膝关节 OA 患者 SF 生物标志物的系统评价。搜索仅限于过去 20 年关于人类研究的文章,涉及膝关节 OA 患者,报告 SF 生物标志物。每个选定的 SF 生物标志物的证据根据 6 类 BIPED 分类进行量化。

结果

共有 159 篇文章被纳入定性数据合成,并确定了 201 种不同的 SF 生物标志物。其中,有几个在不同的文章中进行了多次研究,总共进行了 373 次分析。这些研究包括 13,557 名膝关节 OA 患者。最有希望的 SF 生物标志物是 C4S、IL-6、IL-8、Leptin、MMP-1/3、TIMP-1、TNF-α 和 VEGF。“疾病负担”和“诊断”类别分别以 132 和 106 种不同的生物标志物代表最多。

结论

系统评价确定了许多 SF 生物标志物。然而,尽管对大量已鉴定分子进行了大量研究,但有关每种生物标志物功效的证据却得到了有限且经常相互矛盾的发现的支持。需要进一步的研究工作来提高对 SF 生物标志物的理解,以便更好地管理膝关节 OA 患者。

更新日期:2020-07-25
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