Antimicrobial resistance is one of the key issues limiting the successful treatment of infectious diseases and associated with adverse medical, social and economic consequences on a global scale. The present study aims to evaluate antimicrobials prescribing patterns and assess progress in quality indicators in Russian multidisciplinary hospitals using three repetitive point prevalence studies (PPSs) over 4 years (Global-PPS 2015, 2017 and 2018). Out of 13,595 patients from 21 hospitals surveyed over the three time points, 3542 (26.14%) received antimicrobials, predominantly third-generation cephalosporins (44.7% in 2015, 34.1% in 2017 and 41.8% in 2018). Compliance with the hospital antibiotic guidelines was 74.8%, 66.8% and 74.3%, respectively. Indication for treatment was recorded in 72.6%, 84.1% and 82.6%, while stop/review date was documented only in 40.5%, 46.5% and 61.1% of cases. Perioperative antibiotic prophylaxis exceeded 1 day in 92%, 84% and 81% of cases. Targeted therapy rate at all time points did not exceed 15.1%, treatment based on the biomarkers rate—19.9%. For the part of PPS-2017 and 2018 analyzed in dynamics, no prominent trends were noted. The results of the project provide the basis for the development of appropriate antimicrobial stewardship programs tailored according to local practices for each hospital in the project.

中文翻译：

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俄罗斯医院抗菌药物消费的纵向流行率调查：Global-PPS项目的结果。

抗菌素耐药性是限制感染性疾病成功治疗的关键问题之一，并在全球范围内与不良的医学，社会和经济后果相关。本研究旨在评估俄罗斯多学科医院抗菌药物的处方模式并评估质量指标的进展，历时4年（三项重复性点患病率研究（PPSs））（Global-PPS 2015、2017和2018）。在三个时间点接受调查的21家医院的13595名患者中，有3542名（26.14％）接受了抗生素治疗，主要是第三代头孢菌素（2015年为44.7％，2017年为34.1％，2018年为41.8％）。符合医院抗生素指南的比例分别为74.8％，66.8％和74.3％。记录的治疗指征为72.6％，84.1％和82.6％，停止/复查日期仅记录在40.5％，46.5％和61.1％的案例中。92％，84％和81％的患者围手术期抗生素预防超过1天。在所有时间点的靶向治疗率均不超过15.1％，基于生物标志物的治疗率为19.9％。对于PPS-2017和2018年进行动态分析的部分，未发现明显的趋势。该项目的结果为根据当地实践为该项目中的每家医院量身定制合适的抗菌素管理计划提供了基础。没有发现明显的趋势。该项目的结果为根据当地实践为该项目中的每家医院量身定制合适的抗菌素管理计划提供了基础。没有发现明显的趋势。该项目的结果为根据当地实践为该项目中的每家医院量身定制合适的抗菌素管理计划提供了基础。