MR spectroscopy in a patient with hyponatremic encephalopathy due to the syndrome of inappropriate secretion of antidiuretic hormone revealed decreased N-acetyl-aspartate, creatine plus phosphocreatine, choline-containing compounds, and myo-inositol, with normal glutamate and increased glutamine, which normalized after Na normalization. The decreased concentrations of creatine plus phosphocreatine, choline-containing compounds and myo-inositol are explained by their release as osmolytes from brain cells to adapt to hypo-osmolality induced cerebral edema. Increased glutamine, which not only acts as an osmolyte but also protects neurons under excitotoxic conditions, may suggest that a disrupted glutamate-glutamine cycle may play an important role in the pathogenesis of hyponatremic encephalopathy.

中文翻译：

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磁共振波谱评估低钠性脑病的神经化学

一例抗利尿激素分泌异常综合征导致的低钠性脑病患者的 MR 波谱显示 N-乙酰天冬氨酸、肌酸加磷酸肌酸、含胆碱化合物和肌醇减少，谷氨酸正常，谷氨酰胺增加，之后恢复正常。 Na 归一化。肌酸加磷酸肌酸、含胆碱的化合物和肌醇的浓度降低可以通过它们作为渗透剂从脑细胞中释放出来以适应低渗透压引起的脑水肿来解释。增加的谷氨酰胺不仅作为渗透剂而且在兴奋毒性条件下保护神经元，这可能表明谷氨酸-谷氨酰胺循环被破坏可能在低钠性脑病的发病机制中起重要作用。