Composites of hydroxyapatite (HA) and Bioglass® (BG) have been prepared to evaluate their physical, chemical, and biochemical characteristics. Several researchers have attempted to prepare these types of composites to combine the appealing characteristics of BG (such as high bioactivity and osteoinduction) with those of HA. The sintering temperature for the HA–BG composite system used in previous studies was ≥ 1200°C, which yielded excessive chemical reaction between the precursors (resulting in undesirable biological characteristics), even with addition of as little as 2.5 wt.% BG. In this study, the sintering was performed at 1130°C, slightly below the melting point of BG of 1200°C. This lower sintering temperature prevents excessive reactions between the precursors even with BG content as high as 10 wt.%. The absence of undesirable phases (containing BG < 10 wt.%) resulted in enhanced bioactivity and moderate resorption rate.

中文翻译：

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用于骨组织修复的羟基磷灰石-Bioglass® 复合支架的合成、表征和体外生化分析

已经制备了羟基磷灰石 (HA) 和 Bioglass® (BG) 的复合材料来评估它们的物理、化学和生化特性。一些研究人员试图制备这些类型的复合材料，以将 BG 的吸引人的特性（例如高生物活性和骨诱导）与 HA 的特性结合起来。先前研究中使用的 HA-BG 复合系统的烧结温度≥ 1200°C，即使添加低至 2.5 wt.% 的 BG，也会在前体之间产生过度的化学反应（导致不良的生物学特性）。在本研究中，烧结温度为 1130°C，略低于 BG 的熔点 1200°C。即使 BG 含量高达 10 wt.%，这种较低的烧结温度也能防止前体之间的过度反应。