Two new tricyclic alkaloids (1 and 2), together with three known (3–5) alkaloids, were isolated from the whole plants of Thalictrum cultratum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–5 were tested for their anti-rotavirus activity. The results revealed that compounds 1–5 exhibited potent anti-rotavirus activity with therapeutic index (TI) values in the range 10.7–17.7.

中文翻译：

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来自海棠全植物的生物活性生物碱

两种新的三环生物碱（1 和 2），以及三种已知的（3-5）生物碱，是从 Thalictrum cultratum 的整个植物中分离出来的。它们的结构是通过 HR-ESI-MS 和广泛的 1D 和 2D NMR 光谱研究确定的。测试了化合物 1-5 的抗轮状病毒活性。结果表明，化合物 1-5 表现出有效的抗轮状病毒活性，治疗指数 (TI) 值在 10.7-17.7 范围内。