Postpartum inflammation is a natural and necessary response; however, a dysfunctional inflammatory response can be detrimental to animal productivity. The objective of this study was to determine the effects of a non-steroidal anti-inflammatory drug (meloxicam) on ewe postpartum inflammatory response, ewe plasma polyunsaturated fatty acid and oxylipid concentrations, and lamb growth. After lambing, 36 Hampshire and Hampshire × Suffolk ewes were sequentially assigned within type of birth to control (n = 17) or meloxicam orally administered on d 1 and 4 of lactation (MEL; 90 mg, n = 19). Milk and blood samples were collected on d 1 (prior to treatment) and d 4. Milk glucose-6-phosphate was not affected by MEL. Plasma haptoglobin (Hp) concentrations were less for MEL ewes; control ewes with greater d 1 Hp concentrations had elevated Hp on d 4, but this was not the case for MEL-treated ewes. Treatment with MEL increased plasma arachidonic acid concentration by more than 4-fold in ewes rearing singles but decreased concentrations of 9,10-dihydroxyoctadecenoic acid, prostaglandin F2α, 8-iso-prostaglandin E2, and 8,9-dihydroxyeicosatetraenoic acid. Nine oxylipids in plasma had interactions of treatment with d 1 Hp concentration, all of which revealed positive associations between d 1 Hp and d 4 oxylipid concentrations for CON, but neutral or negative relationships for MEL. MEL decreased 13-hydroxyoctadecadienoic acid:13-oxooctadecadienoic acid ratio and tended to increase 9-hydroxyoctadecadienoic acid:9-oxooctadecadienoic acid ratio (both dependent on d 1 values), indicating progressive metabolism of linoleic acid-derived oxylipids occurred by enzymatic oxidation after MEL treatment. Meloxicam reduced oxylipids generated across oxygenation pathways, potentially due to an improved redox state. Postpartum MEL treatment of ewes decreased plasma concentrations of Hp and several oxylipids, with the greatest impact in ewes with biomarkers reflecting a greater inflammatory state before treatment. Anti-inflammatory strategies may help resolve excessive postpartum inflammation in some dams.

中文翻译：

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产后服用美洛昔康会改变产后母羊的血浆结合珠蛋白、多不饱和脂肪酸和氧脂浓度。

产后炎症是一种自然而必要的反应；然而，功能失调的炎症反应可能会损害动物的生产力。本研究的目的是确定非甾体抗炎药（美洛昔康）对母羊产后炎症反应、母羊血浆多不饱和脂肪酸和氧脂浓度以及羔羊生长的影响。产羔后，36 只 Hampshire 和 Hampshire × Suffolk 母羊按出生类型依次分配到对照组（n = 17）或在哺乳期第 1 天和第 4 天口服美洛昔康（MEL；90 mg，n = 19）。在第 1 天（治疗前）和第 4 天收集牛奶和血液样本。牛奶 6-磷酸葡萄糖不受 MEL 影响。MEL 母羊的血浆触珠蛋白 (Hp) 浓度较低；具有较高 d 1 Hp 浓度的对照母羊在 d 4 时 Hp 升高，但对于 MEL 处理的母羊，情况并非如此。在单只饲养的母羊中，用 MEL 处理使血浆花生四烯酸浓度增加了 4 倍以上，但降低了 9,10-二羟基十八碳烯酸、前列腺素 F2α、8-异前列腺素 E2 和 8,9-二羟基二十碳四烯酸的浓度。血浆中的九种血脂与 d 1 Hp 浓度有交互作用，所有这些都显示 d 1 Hp 和 d 4 血脂浓度与 CON 呈正相关，但与 MEL 呈中性或负相关。MEL 降低了 13-羟基十八碳二烯酸：13-氧代十八碳二烯酸的比率，并倾向于增加 9-羟基十八碳二烯酸：9-氧代十八碳二烯酸的比率（均取决于 d 1 值），表明 MEL 后通过酶促氧化发生亚油酸衍生的氧脂质的进行性代谢治疗。美洛昔康减少了氧化途径产生的氧脂，这可能是由于氧化还原状态的改善。母羊的产后 MEL 治疗降低了 Hp 和几种氧脂的血浆浓度，对母羊的影响最大，其生物标志物反映了治疗前更大的炎症状态。抗炎策略可能有助于解决一些水坝的过度产后炎症。