The correct folding is a key process for a protein to acquire its functional structure and conformation. Prefoldin is a well-known chaperone protein that regulates the correct folding of proteins. Prefoldin plays a crucial role in the pathogenesis of common neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease). The important role of prefoldin in emerging fields (such as nanoparticles, biomaterials) and tumors has attracted widespread attention. Also, each of the prefoldin subunits has different and independent functions from the prefoldin complex. It has abnormal expression in different tumors and plays an important role in tumorigenesis and development, especially c-Myc binding protein MM-1. MM-1 can inhibit the activity of c-Myc through various mechanisms to regulate tumor growth. Therefore, an in-depth analysis of the complex functions of prefoldin and their subunits is helpful to understand the mechanisms of protein misfolding and the pathogenesis of diseases caused by misfolded aggregation.

中文翻译：

---

前折叠蛋白复合物和前折叠蛋白亚基的功能和机制。

正确的折叠是蛋白质获得其功能结构和构象的关键过程。前折叠蛋白是一种众所周知的伴侣蛋白，可调节蛋白质的正确折叠。Prefoldin 在常见神经退行性疾病（阿尔茨海默病、帕金森病和亨廷顿病）的发病机制中发挥着至关重要的作用。前折叠蛋白在新兴领域（如纳米颗粒、生物材料）和肿瘤中的重要作用引起了广泛关注。此外，每个前折叠蛋白亚基具有与前折叠蛋白复合物不同且独立的功能。它在不同肿瘤中存在异常表达，在肿瘤发生发展中发挥重要作用，尤其是c-Myc结合蛋白MM-1。MM-1可以通过多种机制抑制c-Myc的活性来调节肿瘤的生长。因此，深入分析前折叠蛋白及其亚基的复杂功能有助于理解蛋白质错误折叠的机制以及错误折叠聚集引起的疾病的发病机制。