With the acceleration of urbanization and aging and the change of lifestyle, inflammatory diseases have become one of the important threats to the health of the global population. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are involved in the metabolism of extracellular matrix (ECM). They play a key role in inflammation-related diseases. Factors such as inflammation, oxidative stress and growth factors stimulate the production of MMPs with subsequent ECM remodeling. Recently, the studies of epigenetic regulation, including the ability to predict disease progression, important pathophysiological deficiencies as well as treatment methods have been extensively discussed. This article reviews the current studies on epigenetic alterations in MMPs during inflammatory response. It is likely to provide new insights into development of efficient medications of epigenetic therapy for inflammatory diseases.

中文翻译：

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炎症性疾病中基质金属蛋白酶的表观遗传调控：叙述性综述。

随着城市化和老龄化的加速以及生活方式的改变，炎症性疾病已成为全球人口健康的重要威胁之一。基质金属蛋白酶（MMP）和金属蛋白酶组织抑制剂（TIMP）参与细胞外基质（ECM）的代谢。它们在炎症相关疾病中发挥着关键作用。炎症、氧化应激和生长因子等因素刺激 MMP 的产生，并随后进行 ECM 重塑。最近，表观遗传调控的研究，包括预测疾病进展的能力、重要的病理生理缺陷以及治疗方法，得到了广泛的讨论。本文综述了炎症反应过程中 MMP 表观遗传改变的最新研究。它可能为开发炎症性疾病表观遗传治疗的有效药物提供新的见解。