Long intergenic noncoding RNA p21 was mapped on the human chromosome 6p21.2. Accordingly, it was firstly described by promoting the p53-dependent apoptosis in the mouse. Also, it is a new lncRNA playing some vital roles in the cell cycle, apoptosis, cell proliferation, tumorigenesis, invasion, metastasis, and angiogenesis. In this regard, it was shown that, lincRNA-p21 regulates these biological processes involved in carcinogenesis through various signaling pathways including Notch signaling, JAK2/STAT3, and AKT/mTOR pathways. Another mechanism by that lincRNA-p21 can affect these processes is a cross-talk with different miRNAs. In vitro and in vivo studies revealed dysregulation of lincRNA-p21 in various human cancers. In addition, emerging evidence demonstrated that, lincRNA-p21 can be considered as a potential prognostic and therapeutic biomarker in cancers. Also, lincRNA-p21 enhances the response to radiotherapy for colorectal cancer. However, the molecular mechanisms of lincRNA-p21 in carcinogenesis have not been fully elucidated so far. So, this review summarizes the function of lincRNA-p21, as a tumor suppressor factor in different biological processes implicated in cancers.

中文翻译：

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长基因间非编码RNA p21的更新：一种在癌症中具有多种重要功能的调控分子。

长的基因间非编码RNA p21定位在人类染色体6p21.2上。因此，首先描述了通过促进小鼠中p53依赖性细胞凋亡。另外，它是一种新的lncRNA，在细胞周期，凋亡，细胞增殖，肿瘤发生，侵袭，转移和血管生成中起着至关重要的作用。就这一点而言，已表明，lncRNA-p21通过各种信号途径（包括Notch信号传导，JAK2 / STAT3和AKT / mTOR途径）调节参与致癌作用的这些生物学过程。lincRNA-p21可以影响这些过程的另一个机制是与不同miRNA的串扰。体外和体内研究表明，在各种人类癌症中，lincRNA-p21的失调。此外，新出现的证据表明，lincRNA-p21可被认为是癌症中潜在的预后和治疗生物标志物。另外，lincRNA-p21增强了对结直肠癌放射治疗的反应。但是，到目前为止，还没有完全阐明lincRNA-p21在致癌中的分子机制。因此，本综述总结了lincRNA-p21的功能，它是与癌症有关的不同生物学过程中的肿瘤抑制因子。