Thanks to the advancement in science and technology and a significant number of cancer research programs being carried out throughout the world, the prevention, prognosis and treatment of breast cancer are improving with a positive and steady pace. However, a stern thoughtful attention is required for the metastatic breast cancer cases—the deadliest of all types of breast cancer, with a character of relapse even when treated. In an effort to explore the less travelled avenues, we summarize here studies underlying the aspects of histone epigenetics in breast cancer metastasis. Authoritative reviews on breast cancer epigenetics are already available; however, there is an urgent need to focus on the epigenetics involved in metastatic character of this cancer. Here we put forward a comprehensive review on how different layers of histone epigenetics comprising of histone chaperones, histone variants and histone modifications interplay to create breast cancer metastasis landscape. Finally, we propose a hypothesis of integrating histone-epigenetic factors as biomarkers that encompass different breast cancer subtypes and hence could be exploited as a target of larger population.

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三层组蛋白表观遗传学在乳腺癌转移中的作用

得益于科学技术的进步以及全世界范围内开展的大量癌症研究计划，乳腺癌的预防，预后和治疗正在以积极，稳定的步伐得到改善。但是，转移性乳腺癌病例需要经过深思熟虑的关注，这是所有类型乳腺癌中最致命的，即使治疗也具有复发的特征。为了探索人迹罕至的途径，我们在这里总结了乳腺癌转移中组蛋白表观遗传学方面的基础研究。关于乳腺癌表观遗传学的权威评论已经存在。然而，迫切需要关注与该癌症转移特性有关的表观遗传学。在这里，我们对由组蛋白伴侣，组蛋白变体和组蛋白修饰组成的不同组蛋白表观遗传学的不同相互作用如何构成乳腺癌转移景观提出了全面的综述。最后，我们提出了一个假设，即将组蛋白表观遗传因子整合为涵盖不同乳腺癌亚型的生物标志物的假设，因此可以作为更大人群的靶标。