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New insights into the cellular activities of Fndc5/Irisin and its signaling pathways
Cell and Bioscience ( IF 7.5 ) Pub Date : 2020-03-30 , DOI: 10.1186/s13578-020-00413-3
Farzaneh Rabiee , Liana Lachinani , Sarvenaz Ghaedi , Mohammad Hossein Nasr-Esfahani , Timothy L. Megraw , Kamran Ghaedi

Fndc5, a well-defined myokine and also identified as an adipokine, has a critical role in modulation of metabolism and protection against obesity. These important functions are mediated by irisin, a secretory peptide produced from proteolytic processing of Fndc5. The other beneficial physiological effects of irisin are alleviation of oxidative stress, neuroprotective effects, and anti-inflammatory properties and associated anti-metastatic effects. Fndc5/irisin exerts its biological effects through several intracellular signaling pathways. The major signaling pathway is thought to be MAPK signaling pathways which are involved in neural differentiation, browning of white adipocytes, as well as osteoblast proliferation and differentiation. Other essential functions of Fndc5/irisin are mediated through additional pathways including AMPK pathway, PI3K/AKT, and STAT3/Snail. Thorough understanding of the mechanisms of irisin actions are essential in order to develop Fndc5/irisin for therapeutic purposes. In the present review, we focus on the current knowledge of the signaling pathways that elicit irisin actions.

中文翻译:

Fndc5 / Irisin的细胞活性及其信号传导途径的新见解

Fndc5是一种定义明确的肌肉因子,也被确定为脂肪因子,在调节新陈代谢和预防肥胖方面起着至关重要的作用。这些重要功能由虹膜素介导,虹膜素是由Fndc5的蛋白水解过程产生的一种分泌肽。虹膜素的其他有益的生理作用是减轻氧化应激,神经保护作用,抗炎特性和相关的抗转移作用。Fndc5 / irisin通过几种细胞内信号传导途径发挥其生物学作用。认为主要的信号传导途径是MAPK信号传导途径,其参与神经分化,白色脂肪细胞褐变以及成骨细胞增殖和分化。Fndc5 / irisin的其他基本功能是通过其他途径介导的,包括AMPK途径,PI3K / AKT和STAT3 / Snail。为了开发用于治疗目的的Fndc5 / irisin,必须全面了解虹膜素的作用机制。在当前的审查中,我们专注于引起虹膜虹膜动作的信号通路的当前知识。
更新日期:2020-03-30
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