Doxorubicin-loaded hollow gold nanospheres (Dox@HAuNS) are a promising technology for simultaneous trans-arterial tumor-targeted chemotherapy delivery and thermal ablation. We evaluated the efficacy of intra-arterial delivery of Dox@HAuNS followed by photothermal ablation (PTA) in a rabbit model of liver cancer. Adult New Zealand white rabbits (N = 25) were inoculated with VX2 tumors into the left lobe of the liver. The animals were then randomized to sham surgery (N = 5), PTA only (N = 3), Dox@HAuNS only (N = 5), HAuNS + PTA (N = 5), and Dox@HAuNS + PTA (N = 7). Nanoparticles were delivered as an emulsion with Lipiodol (Guerbet, France) via a trans-arterial approach. Following nanoparticle delivery, PTA was performed using an 808-nm fibered laser at 1.5 W for 3 min. Thermography during PTA demonstrated a sustained elevation in tumoral temperature in both HAuNS + laser and Dox@HAuNS + laser treatment groups relative to animals that underwent laser treatment without prior nanoparticle delivery. There was a significant decrease in tumor volumes in all three treatment arms relative to control arms (P = 0.004). Concentrations of intratumoral doxorubicin were significantly greater in animals treated with laser compared to those that were not treated with laser (P < 0.01). Doxorubicin-loaded HAuNS is a promising therapeutic agent for dual ablation/chemoembolization treatment of liver cancer.

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负载多柔比星的空心金纳米球用于双重光热消融和化学栓塞治疗

负载多柔比星的空心金纳米球（Dox@HAuNS）是一种很有前途的技术，可用于同时进行经动脉肿瘤靶向化疗和热消融。我们在兔肝癌模型中评估了动脉内递送 Dox@HAuNS 然后进行光热消融 (PTA) 的疗效。将 VX2 肿瘤接种到成年新西兰白兔 (N = 25) 的肝左叶。然后将动物随机分配至假手术组 (N = 5)、仅 PTA (N = 3)、仅 Dox@HAuNS (N = 5)、HAuNS + PTA (N = 5) 和 Dox@HAuNS + PTA (N = 7）。纳米颗粒通过经动脉途径与碘油 (Guerbet, France) 一起作为乳剂递送。在纳米颗粒递送后，使用 808 nm 光纤激光器在 1.5 W 下进行 PTA 3 分钟。PTA 期间的热成像显示 HAuNS + 激光和 Dox@HAuNS + 激光治疗组的肿瘤温度持续升高，相对于未经纳米颗粒递送而接受激光治疗的动物。与对照组相比，所有三个治疗组的肿瘤体积均显着减少（P = 0.004）。与未接受激光治疗的动物相比，接受激光治疗的动物的瘤内阿霉素浓度显着高于未接受激光治疗的动物（P < 0.01）。负载多柔比星的HAuNS是一种很有前途的肝癌消融/化疗栓塞双重治疗药物。与对照组相比，所有三个治疗组的肿瘤体积均显着减少（P = 0.004）。与未接受激光治疗的动物相比，接受激光治疗的动物的瘤内阿霉素浓度显着高于未接受激光治疗的动物（P < 0.01）。负载多柔比星的HAuNS是一种很有前途的肝癌消融/化疗栓塞双重治疗药物。与对照组相比，所有三个治疗组的肿瘤体积均显着减少（P = 0.004）。与未接受激光治疗的动物相比，接受激光治疗的动物的瘤内阿霉素浓度显着高于未接受激光治疗的动物（P < 0.01）。负载多柔比星的HAuNS是一种很有前途的肝癌消融/化疗栓塞双重治疗药物。