N6-methyladenosine (m6A) is the most abundant form of mRNA modification in eukaryotes. It affects various aspects of RNA metabolism, including nuclear export, translation, decay and alternative splicing. In addition, m6A also participates in a great number of human physiological processes, ranging from spermatogenesis modulation, response to heat shock, the control of T cell homeostasis to stem cell proliferation and differentiation. The dynamic equilibrium of m6A level is regulated by m6A methyltransferases (“writers”), m6A demethylases (“erasers”) as well as m6A-binding proteins (“readers”). Once the balance is broken, numerous diseases will knock on the door. Recently, increasing studies reveal that m6A methylation exerts a profound impact on tumorigenesis and tumor progression. Therefore, in this review, we summarize the functions of m6A modification and its emerging roles in human cancers, and discuss the potential of m6A regulators as biomarkers or therapeutic targets.

中文翻译：

---

N6-甲基腺苷RNA甲基化在人类癌症中的新兴作用。

N6-甲基腺苷（m6A）是真核生物中最丰富的mRNA修饰形式。它影响RNA代谢的各个方面，包括核输出，翻译，衰变和选择性剪接。此外，m6A还参与了许多人类生理过程，包括生精调节，热休克反应，T细胞稳态控制到干细胞增殖和分化。m6A水平的动态平衡受m6A甲基转移酶（“编写者”），m6A脱甲基酶（“擦除者”）以及m6A结合蛋白（“读者”）调节。一旦天平被打破，无数的疾病将敲门。最近，越来越多的研究表明，m6A甲基化对肿瘤发生和肿瘤进展具有深远的影响。因此，在这篇评论中，