Nigella sativa L. seed commonly known as black seed, extensively used as a folk medicine in Middle East and Asian subcontinent. Traditionally it is used as an adjunct therapy along with modern medicine to counter the adverse effects. Pure thymoquinone or isolated compounds are not free from adverse effects. The present study was undertaken to evaluate N. sativa seeds powder impact on the fluconazole (FLZ) induced toxicities in the liver and kidneys. Male Wistar rats were acclimatized, divided into four groups each group with six animals. Experimental animals were subjected to an FLZ dose of 50 mg per kg of body mass. The toxic effects of FLZ treatment were manifested and animals were given 1000 mg of N. sativa seeds powder per kg of body weight to observe any retrieval. Dissected animals were evaluated for biochemical and histopathology alterations. Based on findings, it can be concluded that N. sativa seeds powder restored various altered biochemical parameters induced by fluconazole and can be used along with fluconazole in the treatment of fungal infections.

普通黑种子（Nigella sativa L.）种子通常被称为黑种子，在中东和亚洲次大陆广泛用作民间药物。传统上，它与现代医学一起用作辅助疗法，以对抗不良反应。纯的胸腺醌或分离的化合物没有不良影响。本研究旨在评估苜蓿种子粉对氟康唑（FLZ）诱导的肝脏和肾脏毒性的影响。使雄性Wistar大鼠适应，分成四组，每组六只动物。实验动物接受每公斤体重50 mg的FLZ剂量。表现出FLZ治疗的毒性作用，并向动物饲喂1000毫克的苜蓿猪笼草每公斤体重可撒种子粉，观察是否恢复。评估解剖动物的生化和组织病理学改变。根据发现，可以得出结论：苜蓿种子粉恢复了氟康唑诱导的各种改变的生化参数，可以与氟康唑一起用于治疗真菌感染。