Abstract

In this study, elastic styrene–butadiene–styrene (SBS), non-elastic SBS and their blends at different ratios were electrospun into fibrous membranes and their cell biocompatibility was evaluated. The as-spun fibers showed an average fiber diameter of 2 µm, and the fibrous membranes had pore size of 8 ± 0.01 µm. The blending ratios of the elastic with non-elastic SBSs showed little effect on fibrous structure, but affected the mechanical properties. All SBS membrane showed no cytotoxicity on endothelial cells (ECs). ECs attached and proliferated on all the SBS fibrous membrane scaffolds regardless of their elasticity. ECs maintained their polygonal shape on the scaffolds and they tended to orient along the fiber length. The SBS fibrous samples with elastic:non-elastic SBS weight ratios of 1:1 and 2:3 showed better cell viability than that of elastic and non-elastic SBS.

摘要

在这项研究中，将弹性苯乙烯-丁二烯-苯乙烯 (SBS)、非弹性 SBS 及其不同比例的混合物电纺成纤维膜，并评估了它们的细胞生物相容性。初纺纤维的平均纤维直径为 2 µm，纤维膜的孔径为 8 ± 0.01 µm。弹性与非弹性SBSs的混合比例对纤维结构影响不大，但对力学性能有影响。所有 SBS 膜对内皮细胞 (EC) 均无细胞毒性。无论弹性如何，ECs 都附着在所有 SBS 纤维膜支架上并增殖。ECs 在支架上保持其多边形形状，并且它们倾向于沿着纤维长度定向。弹性：非弹性 SBS 重量比为 1:1 和 2 的 SBS 纤维样品：