Abstract

Among many compounds that due to their properties are widely used for preparation of ceramic composites applicable in medicine is hydroxyapatite (HAp) characterized by good osteoconductivity and osteoinductivity. Additionally, it enables the adhesion and proliferation of cells and contributes to the fixation of the interaction between the implant and the bone tissue. In presented research, a series of composites with HAp has been obtained. Firstly, HAp has been synthesized by two different methodologies. The methodology of the synthesis of HAp affected its microstructure and the surface morphology that was caused by the different temperature conditions. Both obtained HAp powders met the ISO requirements, that assume that the Ca/P ratio should be within the range 1.5 − 2.0, which qualifies the biomaterial for further investigations. Next, HAp powders were introduced into the polymer matrices based on collagen, gelatin and polyvinylpyrrolidone. The additives were uniformly dispersed in the polymer matrix that was proved by SEM analysis. Composites exhibited low swelling ability and stability in simulated physiological liquids. It can be concluded that the developed composites due to their components and properties constitute interesting materials that can be considered for the use in such areas as tissue engineering or implantology.

摘要

羟基磷灰石 (HAp) 由于其特性而被广泛用于制备可用于医学的陶瓷复合材料，其中羟基磷灰石 (HAp) 具有良好的骨传导性和骨诱导性。此外，它还能促进细胞的粘附和增殖，并有助于固定植入物和骨组织之间的相互作用。在目前的研究中，已经获得了一系列具有 HAp 的复合材料。首先，HAp 是通过两种不同的方法合成的。HAp 的合成方法影响其微观结构和由不同温度条件引起的表面形态。两种获得的 HAp 粉末均符合 ISO 要求，即假设 Ca/P 比率应在 1.5 - 2.0 范围内，这使生物材料有资格进行进一步研究。下一个，HAp 粉末被引入到基于胶原蛋白、明胶和聚乙烯吡咯烷酮的聚合物基质中。SEM 分析证明，添加剂均匀地分散在聚合物基体中。复合材料在模拟生理液体中表现出低溶胀能力和稳定性。可以得出结论，开发的复合材料由于其成分和特性构成了有趣的材料，可以考虑用于组织工程或植入学等领域。