Abstract

Oxetane-grafted chitosan-modified polyurethane (OXE-CHI-PU) with a photo-initiator camphorquinone (CQ) added was used as a bio-adhesive to heal wounds. The curing mechanism, photodynamic, healing effect, adhesion, biodegradability, and cell viability analyses of OXE-CHI-PU were established and conducted. After application, it can be cured and healed with a 20 W blue light source. The addition of OXE-CHI can improve the healing effect and the optimum ratio is determined to be OXE-CHI-PU with 1% CQ added. This material has good biocompatibility and biodegradability, it is hoped that the bioadhesive of this study can be successfully applied to the healing of wounds.

摘要

添加了光引发剂樟脑醌 (CQ) 的氧杂环丁烷接枝壳聚糖改性聚氨酯 (OXE-CHI-PU) 用作生物粘合剂来愈合伤口。建立并进行了OXE-CHI-PU的固化机理、光动力学、愈合效果、粘附、生物降解性和细胞活力分析。涂抹后，可以用20W蓝光光源进行固化和愈合。OXE-CHI的加入可提高愈合效果，确定最佳配比为OXE-CHI-PU加1%CQ。该材料具有良好的生物相容性和生物降解性，希望本研究的生物粘合剂能够成功应用于伤口愈合。