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Grafting of glycine, alanine, serine, and threonine on cellulose membranes and their role in regulating the uniport, symport, and antiport permeation of glucose
International Journal of Polymeric Materials and Polymeric Biomaterials ( IF 3.2 ) Pub Date : 2020-07-02 , DOI: 10.1080/00914037.2020.1785459
Isam M. Arafa 1 , Mazin Y. Shatnawi 1 , Mohammad H. Abdallah 1 , Zaher A. Algharaibeh 2
Affiliation  

Abstract

Four cellulose membranes were grafted with glycine, L-alanine, L-serine, and L-threonine amino acids. The grafted membranes were characterized by different physicochemical techniques (ATR-IR, gravimetry, thermal degradation and ninhydrin test). The degree of substitution was found to range from 0.29 to 0.85 per glycoside unit, mainly occurring at C6. This structural modification was further examined and found to modestly alter the thickness, hydrophilicity, pore size, porosity, tortuosity, and flux behavior of the native Cell-OH membranes. Accordingly, the performance of the modified membranes toward the permeation of D-glucose (D-Glu) was investigated in the presence of NaCl, KCl, and NaHCO3 salts under uniport, symport, and antiport conditions. Data analysis allows the inspection of the role played by [Na]+/[K]+ cations and [Cl]-/[HCO3]- in the permeation process of D-Glu. All data were examined in comparison with those obtained for the native Cell-OH membrane. The introduced functionalities are found to hinder the passage D-Glu under uniport conditions, while dramatically affect the symport and antiport migrations. The modified membranes facilitate the passage of D-Glu in symport mode where the anions (Cl- and HCO3_) play a key role in comparison with the cations (Na+, K+). However, the role of both cations and anions is seen in the antiport mode.



中文翻译:

甘氨酸、丙氨酸、丝氨酸和苏氨酸在纤维素膜上的嫁接及其在调节葡萄糖单向、同向和反向渗透中的作用

摘要

四种纤维素膜接枝有甘氨酸、L-丙氨酸、L-丝氨酸和L-苏氨酸氨基酸。通过不同的物理化学技术(ATR-IR、重量分析、热降解和茚三酮测试)表征接枝膜。发现取代度范围为每个糖苷单元 0.29 至 0.85,主要发生在 C 6 处。进一步检查了这种结构修饰,发现其适度改变了天然 Cell-OH 膜的厚度、亲水性、孔径、孔隙率、弯曲度和通量行为。因此,研究了在 NaCl、KCl 和 NaHCO 3存在下改性膜对 D-葡萄糖 (D-Glu) 渗透的性能单向、同向和反向条件下的盐。数据分析允许检查 [Na] + /[K] +阳离子和 [Cl] - /[HCO 3 ] -在 D-Glu 渗透过程中所起的作用。将所有数据与从天然 Cell-OH 膜获得的数据进行比较。发现引入的功能会阻碍 D-Glu 在单端口条件下的通过,同时显着影响同向和反向迁移。改性膜促进 D-Glu 在同向模式下通过,其中阴离子(Cl -和 HCO 3 _)与阳离子(Na +、K +)。然而,在反端口模式中可以看到阳离子和阴离子的作用。

更新日期:2020-07-02
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