Abstract

A new kind of redox responsive nanoparticles was prepared through the modification and crosslinking reaction of xanthan gum. The nanoparticles had regular spherical shapes with diameters ranging from 110 to 180 nm. The nanoparticles showed good redox responsiveness. Doxorubicin (DOX) was loaded in the nanoparticles via ionic interaction with SO₃^-, for increasing the drug loading rate and avoiding drug leakage. The in vitro drug release could be controlled by pH and reduction conditions simulated to the internal environment of tumor cells. The nanoparticles were biocompatible and could be potentially applied as anti-cancer drug vehicles for targeted release.

摘要

通过黄原胶的改性和交联反应制备了一种新型氧化还原响应纳米粒子。纳米颗粒具有规则的球形，直径范围为 110 至 180 nm。纳米颗粒表现出良好的氧化还原响应性。多柔比星（DOX）通过与SO ₃ ^{- 的}离子相互作用负载在纳米颗粒中，以提高药物负载率并避免药物泄漏。的体外药物释放可通过模拟到肿瘤细胞的内部环境的pH和还原条件来控制。纳米颗粒具有生物相容性，可能用作靶向释放的抗癌药物载体。