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Viscoelasticity, mechanical properties, and in vivo biocompatibility of injectable polyvinyl alcohol/bioactive glass composite hydrogels as potential bone tissue scaffolds
International Journal of Polymer Analysis and Characterization ( IF 1.9 ) Pub Date : 2020-07-03 , DOI: 10.1080/1023666x.2020.1790253
Ahmed Abd El-Fattah 1, 2 , Mohamad Nageeb Hassan 1, 3 , Ahmad Rashad 1, 3 , Mona Marei 4 , Sherif Kandil 1
Affiliation  

Abstract An injectable composite hydrogel composed of polyvinyl alcohol (PVA) and bioactive glass (BG) particles were synthesized by a physical crosslinking approach. The morphology, mechanical properties, and viscoelasticity of the PVA/BG composite hydrogel were characterized. Scanning electronic microscopy (SEM) showed uniform and homogeneous distribution of BG particles throughout the composite hydrogel. The incorporation of 2.5 wt% of BG particles in the composite hydrogel formulations, enhanced the static compressive strength and static elastic modulus by 325% and 150%, respectively. The storage molds (G′) was greater than the loss modules (G′′) at all the frequency range studied, which revealed a self-standing elastic composite hydrogel with a smooth injectability. The PVA/BG composite hydrogel was also implanted subcutaneously in the dorsal region of adult male rats. After 4 weeks of implantation, no inflammatory cells were seen within and around the implant, which indicated that the composite hydrogel was biocompatible. The properties of the synthesized injectable PVA/BG composite hydrogel demonstrate its capability toward bone regeneration.

中文翻译:

可注射聚乙烯醇/生物活性玻璃复合水凝胶作为潜在骨组织支架的粘弹性、机械性能和体内生物相容性

摘要 通过物理交联方法合成了由聚乙烯醇(PVA)和生物活性玻璃(BG)颗粒组成的可注射复合水凝胶。表征了 PVA/BG 复合水凝胶的形态、机械性能和粘弹性。扫描电子显微镜 (SEM) 显示 BG 颗粒在整个复合水凝胶中均匀分布。在复合水凝胶配方中加入 2.5 wt% 的 BG 颗粒,将静态压缩强度和静态弹性模量分别提高了 325% 和 150%。在研究的所有频率范围内,存储模具 (G') 都大于损耗模块 (G''),这表明自立式弹性复合水凝胶具有平滑的可注射性。PVA/BG 复合水凝胶也被植入到成年雄性大鼠的背部皮下。植入4周后,植入物内部和周围均未见炎症细胞,表明复合水凝胶具有生物相容性。合成的可注射 PVA/BG 复合水凝胶的特性证明其具有骨再生能力。
更新日期:2020-07-03
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