Abstract

A new Cu(II)-based coordination polymer (CP), {[Cu(bpa)(1,3-BDC)(H₂O)](DMF)_n}_n (1), (DMF = dimethylformamide) was synthesized by reaction of the Cu(NO₃)₂·3H₂O with the 3,6-bis(benzimidazol-1-yl)pyridazine (bpa) presence of the isophthalic acid (1,3-H₂BDC). Its intracerebral hemorrhage (ICH) protective treatment was assessed and the related mechanism was explored as well. The real time RT-PCR was used to detect the relative expression levels of the ROS related genes, which reflected the intracellular ROS levels in the vascular endothelial cells. Next, the western blotting assay was performed and the inflammatory responses levels in the vascular endothelial cells were evaluated.

抽象的

合成了一种新的基于Cu（II）的配位聚合物（CP）{[Cu（bpa）（1,3-BDC）（H ₂ O）]（DMF）_n } _n（1），（DMF =二甲基甲酰胺） Cu（NO ₃）₂ ·3H ₂ O与3,6-双（苯并咪唑-1-基）哒嗪（bpa）在间苯二甲酸（1,3-H ₂）存在下的反应BDC）。对其脑出血（ICH）的保护性治疗进行了评估，并探讨了其相关机制。实时RT-PCR用于检测ROS相关基因的相对表达水平，这反映了血管内皮细胞中细胞内ROS的水平。接下来，进行蛋白质印迹分析并评估血管内皮细胞中的炎症反应水平。