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Two Cu(II) co-ordination polymers: anti-cancer activity on melanoma by reducing cancer cell proliferation, migration, and invasion ability
Inorganic and Nano-Metal Chemistry ( IF 1.7 ) Pub Date : 2020-06-27 , DOI: 10.1080/24701556.2020.1783314
Zhaopeng Xuan 1 , Yamei Zhan 1 , Guangyun Song 2 , Bin Liu 1
Affiliation  

Abstract

By using a mixed-ligand approach, two new Cu(II)-containing co-ordination polymers (CPs) with the chemical formula of [Cu4(HDNA)4(4,4′-bpy)(OH)2]·4H2O·2CH3CN (1, H2DNA = 4,4′-dicarboxy-4″-nitrotriphenyl-amine, 4,4′-bpy = 4,4′-bipyridine) and [Cu3(TCA)2(DPE)]·10DMF·6H2O (2, H3TCA = 4,4′,4″-nitrilotribenzoic acid, dpe = (E)-1,2-di(pyridin-4-yl)diazene) have been successfully prepared by reaction of Cu(NO3)2·3H2O with the corresponding organic ligands under the solvothermal conditions. The cancer cell viability and proliferation were determined with Cell Counting Kit-8 (CCK-8) assay and the colony formation assay. The migration and invasion capability of A375 melanoma cells under Cu(II)-based co-ordination polymers treatment was evaluated with trans-well assay.



中文翻译:

两种Cu(II)配位聚合物:通过降低癌细胞的增殖,迁移和侵袭能力,对黑色素瘤具有抗癌活性

通过使用混合配体方法,两种新的化学式为[Cu 4(HDNA)4(4,4'-bpy)(OH)2 ]·4H的含Cu(II)配位聚合物(CP)2 O·2CH 3 CN(1,H 2 DNA = 4,4'-二羧基-4''-硝基三苯胺,4,4'-bpy = 4,4'-联吡啶)和[Cu 3(TCA)2( DPE)]·10DMF·6H 2 O(2,H 3 TCA = 4,4',4″-亚硝基三苯甲酸,dpe =(E)-1,2-二(吡啶-4-基)二氮杂) Cu(NO 32 ·3H 2反应制得在溶剂热条件下具有相应的有机配体。用细胞计数试剂盒8(CCK-8)测定和集落形成测定来确定癌细胞的生存力和增殖。用trans-well法评估了基于铜(II)配位聚合物处理的A375黑色素瘤细胞的迁移和侵袭能力。

更新日期:2020-06-27
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