Abstract

Two new Cu(II)-based coordination polymers (CPs) {[Cu₃(btc)₂(bpfp)₂(H₂O)₂](H₂O)₂}_n (1, H₃btc = 1,2,3-benzenetricarboxylic acid, bpfp = bis(4-pyridylformyl)piperazine) and {[Cu(cca)(bpfp)]·2H₂O}_n (2, H₂cca = 2-carboxycinnamic acid) have been successfully prepared by reaction of Cu(NO₃)₂·3H₂O with the bpfp ligand in the presence of different carboxylate ligands. Compounds 1 and 2 were synthesized for the evaluation of anti-cancer activity on the ovarian cancer cells CoC1. First of all, the cancer cell proliferation, migration and invasion ability were determined. Subsequently, the marker of the ovarian cancer cells-miRNA16 was also measured with real time reverse transcription-polymerase chain reaction (RT-PCR).

两个新的基于Cu（II）的配位聚合物（CPs）{[Cu ₃（btc）₂（bpfp）₂（H ₂ O）₂ ]（H ₂ O）₂ } _n（1，H ₃ btc = 1,2已成功制备了3-苯基三羧酸bpfp =双（4-吡啶基甲酰基）哌嗪）和{[Cu（cca）（bpfp）]·2H ₂ O} _n（2，H ₂ cca = 2-羧肉桂酸）羧酸盐配体存在下Cu（NO ₃）₂ ·3H ₂ O与bpfp配体的反应 化合物1和合成2个用于评估对卵巢癌细胞CoC1的抗癌活性。首先，确定癌细胞的增殖，迁移和侵袭能力。随后，还通过实时逆转录-聚合酶链反应（RT-PCR）测量了卵巢癌细胞标志物miRNA16。