ABSTRACT

A three-component one-pot synthesis of new thiazolyl coumarin derivatives was carried out by condensing 3-acetyl-4-hydroxycoumarin, arylaldehydes, thiourea and ammonium acetate at reflux in DMC. The optimization details of the developed novel protocol are recorded. In addition, we have also synthesized these compounds via another second route in two steps. High atom-economy, excellent yields, simple procedure, and mild reaction conditions are the important features of this one-pot protocol. The chemical structures of the newly synthesized compounds were elucidated by using analytical (IR, ¹H NMR, ¹³C NMR). Further, all the compounds were screened for their antioxidant activities.

摘要

新的噻唑基香豆素衍生物的三组分一锅法合成是通过在DMC中回流3-乙酰基-4-羟基香豆素，芳基醛，硫脲和乙酸铵进行的。记录了开发的新颖协议的优化细节。此外，我们还分两步通过另一种第二途径合成了这些化合物。高原子经济性，优异的收率，简单的步骤和温和的反应条件是此一锅方案的重要特征。通过分析（IR，¹ H NMR，¹³ C NMR）阐明了新合成化合物的化学结构。此外，筛选所有化合物的抗氧化活性。