Both extracellular vesicles (EVs) and long noncoding RNAs (lncRNAs) have been increasingly investigated as biomarkers, pathophysiological mediators, and potential therapeutics. While these two entities have often been studied separately, there are increasing reports of EV‐associated lncRNA activity in processes such as oncogenesis as well as tissue repair and regeneration. Given the powerful nature and emerging translational impact of other noncoding RNAs such as microRNA (miRNA) and small interfering RNA, lncRNA therapeutics may represent a new frontier. While EVs are natural vehicles that transport and protect lncRNAs physiologically, they can also be engineered for enhanced cargo loading and therapeutic properties. In this review, we will summarize the activity of lncRNAs relevant to both tissue repair and cancer treatment and discuss the role of EVs in enabling the potential of lncRNA therapeutics.

中文翻译：

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细胞外小泡相关长非编码RNA的治疗潜力

越来越多地研究了细胞外囊泡（EV）和长非编码RNA（lncRNA）作为生物标志物，病理生理介质和潜在的治疗方法。尽管经常对这两个实体进行单独研究，但越来越多的报道称与EV相关的lncRNA在肿瘤发生，组织修复和再生等过程中具有活性。鉴于其他非编码RNA（如microRNA（miRNA）和小干扰RNA）的强大性质和新兴的翻译影响，lncRNA治疗可能代表了一个新领域。电动汽车是天然运输工具，可在生理上运输和保护lncRNA，但也可以对其进行工程设计，以提高货物装载量和治疗性能。在这篇评论中