Iron biofortification of crops, like wheat, is an attractive strategy to cope with iron deficiency causing hidden hunger. Several recent studies dissected the genetics controlling iron concentrations in wheat grain, and expanded our understanding of iron accumulation in wheat grains. However, successful breeding of iron-rich wheat cultivar is limited based on plant genetics. Along with the wide appreciation of wheat-associated microbes, it is evidenced that microbes have a significant effect on iron concentration in grain and impacted plant genetics. These microbes, together called the plant microbiome, lived in either the rhizosphere (rhizobacteria) or the inner tissues of wheat (endophytes). They have complex genetics and influenced iron uptake, remobilization, accumulation and bioavailability, thereby either direct or indirectly contributed to grain iron biofortification in wheat. Although in rice it has been possible to exceed (60–140 μg Fe/g rice grain) the targeted iron biofortification requirement of 59 μg Fe/g cereal grain, most wheat lines only reach 20–40 μg Fe/g wheat grain. In our opinion, it is necessary to combine both plant and microbial genetics for successful iron biofortification in wheat. Application of microbes, especially engineered endophytes incorporated with plant genes controlling iron accumulation may be an efficient and feasible routine for iron biofortification in wheat.

像小麦一样，作物的铁生物强化是一种应对因铁缺乏引起的潜在饥饿感的有吸引力的策略。最近的一些研究剖析了控制小麦籽粒中铁含量的遗传学，并扩展了我们对小麦籽粒中铁积累的理解。然而，基于植物遗传学，富铁小麦品种的成功育种受到限制。随着对小麦相关微生物的广泛赞赏，有证据表明，微生物对谷物中铁的浓度和影响植物遗传的作用显着。这些微生物共同称为植物微生物组，它们生活在根际（根际细菌）或小麦的内部组织（内生植物）中。它们具有复杂的遗传学，并影响铁的吸收，迁移，积累和生物利用度，因此直接或间接促进了小麦中铁的生物强化。尽管在水稻中有可能超过（60-140μgFe / g谷物）铁的生物强化目标指标，即59μgFe / g谷物，但大多数小麦品系仅达到20-40μgFe / g小麦。我们认为，有必要将植物遗传学和微生物遗传学结合起来，以成功实现小麦中铁的生物强化。微生物的应用，特别是工程化的内生菌与控制铁积累的植物基因结合在一起，可能是小麦中铁生物强化的一种有效可行的方法。我们认为，有必要将植物遗传学和微生物遗传学结合起来，以成功实现小麦中铁的生物强化。微生物的应用，特别是工程化的内生菌与控制铁积累的植物基因结合在一起，可能是小麦中铁生物强化的一种有效可行的方法。我们认为，有必要将植物遗传学和微生物遗传学结合起来，以成功实现小麦中铁的生物强化。微生物的应用，特别是工程化的内生菌与控制铁积累的植物基因结合在一起，可能是小麦中铁生物强化的一种有效可行的方法。