Abstract Safe-by-design is an essential component for creating awareness of the potential novel risks associated with the introduction of sophisticated nanomaterials (NMs) with novel properties. SbD is also a useful tool for meeting EU policy ambitions such as the European Green Deal which includes circular economy and moving towards a zero pollution (pollution-free) environment. Unidentified risks are a growing concern with the rapid and exponential advances of nanotechnology innovation, and the increase in fundamental research on NMs and their potential applications. Therefore, addressing nano-specific safety issues early in the innovation process is vital for reducing the uncertainties of novel NMs. The challenge is that many innovators and material scientists are not toxicologist and are not aware on how to assess the safety of their innovations and novel materials. Safe-by-design is a concept that aims at reducing uncertainties and risks for humans and the environment, starting at an early phase of the innovation process and covering the whole innovation value chain, including research. This perspective tries to get a better understanding on the role of safe-by-design within engineered nanomaterial research to create awareness on the importance on assessing the safety early in research. A method was developed that integrates SbD with a set of questions to aid material scientists assess the safety of their materials (nano-specific safety aspects) and Risk Analysis and Technology Assessment (RATA). Here we present the results of a workshop for material scientists (PhD students) with limited toxicology knowledge at the Debye Institute for Nanomaterials Science (Utrecht University, The Netherlands) with the main goals to create awareness with regard to basic NM safety and to explore the possibilities for applying safe-by-design principles in academia. The approach presented here can be applied by researchers and innovators to assess the safety of NMs at an early stage of the innovation process, and this work is framed in the context of Responsible Research and Innovation using RATA.

中文翻译：

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在学术界实施纳米特定安全和安全设计原则的挑战

摘要 安全设计是提高对引入具有新特性的复杂纳米材料 (NM) 相关的潜在新风险的认识的重要组成部分。SbD 也是实现欧盟政策雄心的有用工具，例如欧洲绿色协议，其中包括循环经济和迈向零污染（无污染）环境。随着纳米技术创新的快速和指数级进步，以及对纳米材料及其潜在应用的基础研究的增加，不明风险越来越受到关注。因此，在创新过程的早期解决纳米特定的安全问题对于减少新型纳米的不确定性至关重要。挑战在于，许多创新者和材料科学家不是毒理学家，也不知道如何评估他们的创新和新材料的安全性。安全设计是一个概念，旨在减少人类和环境的不确定性和风险，从创新过程的早期阶段开始，涵盖整个创新价值链，包括研究。这个观点试图更好地理解设计安全在工程纳米材料研究中的作用，以提高人们对在研究早期评估安全性的重要性的认识。开发了一种方法，将 SbD 与一组问题相结合，以帮助材料科学家评估其材料的安全性（纳米特定的安全方面）以及风险分析和技术评估 (RATA)。在这里，我们展示了德拜纳米材料科学研究所（荷兰乌得勒支大学）毒理学知识有限的材料科学家（博士生）研讨会的结果，其主要目标是提高对基本纳米安全的认识并探索在学术界应用安全设计原则的可能性。研究人员和创新者可以应用这里介绍的方法在创新过程的早期评估 NM 的安全性，并且这项工作是在使用 RATA 的负责任研究和创新的背景下构建的。荷兰）的主要目标是提高对基本 NM 安全的认识，并探索在学术界应用安全设计原则的可能性。研究人员和创新者可以应用这里介绍的方法在创新过程的早期评估 NM 的安全性，并且这项工作是在使用 RATA 的负责任研究和创新的背景下构建的。荷兰）的主要目标是提高对基本 NM 安全的认识，并探索在学术界应用安全设计原则的可能性。研究人员和创新者可以应用这里介绍的方法在创新过程的早期评估 NM 的安全性，并且这项工作是在使用 RATA 的负责任研究和创新的背景下构建的。