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The KiSS-1/GPR54 system: Essential roles in physiological homeostasis and cancer biology
Genes & Diseases ( IF 6.8 ) Pub Date : 2020-07-24 , DOI: 10.1016/j.gendis.2020.07.008
Nisha Zhu 1 , Mengxiang Zhao 1 , Yuxian Song 1 , Liang Ding 1 , Yanhong Ni 1
Affiliation  

KiSS-1, first identified as an anti-metastasis gene in melanoma, encodes C-terminally amidated peptide products, including kisspeptin-145, kisspeptin-54, kisspeptin-14, kisspeptin-13 and kisspeptin-10. These products are endogenous ligands coupled to G protein-coupled receptor 54 (GPR54)/hOT7T175/AXOR12. To date, the regulatory activities of the KiSS-1/GPR54 system, such as puberty initiation, antitumor metastasis, fertility in adulthood, hypothalamic-pituitary-gonadal axis (HPG axis) feedback, and trophoblast invasion, have been investigated intensively. Accumulating evidence has demonstrated that KiSS-1 played a key role in reproduction and served as a promising biomarker relative to the diagnosis, identification of therapeutic targets and prognosis in various carcinomas, while few studies have systematically summarized its subjective factors and concluded the functions of KiSS-1/GPR54 signaling in physiology homeostasis and cancer biology. In this review, we retrospectively summarized the regulators of the KiSS-1/GPR54 system in different animal models and reviewed its functions according to physiological homeostasis regulations and above all, cancer biology, which provided us with a profound understanding of applying the KiSS-1/GPR54 system into medical applications.



中文翻译:

KiSS-1/GPR54 系统:在生理稳态和癌症生物学中的重要作用

KiSS-1首次被鉴定为黑色素瘤中的抗转移基因,编码 C 末端酰胺化肽产物,包括 Kisspeptin-145、kisspeptin-54、kisspeptin-14、kisspeptin-13 和kisspeptin-10。这些产品是与 G 蛋白偶联受体 54 (GPR54)/hOT7T175/AXOR12 偶联的内源性配体。迄今为止,已经深入研究了 KiSS-1/GPR54 系统的调节活动,例如青春期启动、抗肿瘤转移、成年期生育、下丘脑-垂体-性腺轴(HPG 轴)反馈和滋养层侵袭。越来越多的证据表明,KiSS-1KiSS-1/GPR54信号通路在各种癌症的诊断、治疗靶点识别和预后方面发挥着重要作用,但很少有研究系统总结其主观因素并总结KiSS-1/GPR54信号在生理稳态中的作用。和癌症生物学。在这篇综述中,我们回顾性总结了 KiSS-1/GPR54 系统在不同动物模型中的调节作用,并根据生理稳态规律,尤其是癌症生物学对其功能进行了回顾,这为我们提供了应用 KiSS-1 的深刻理解。 /GPR54系统进入医疗应用。

更新日期:2020-07-24
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