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Unclear but present danger: An asymptomatic SARS-CoV-2 carrier.
Genes & Diseases ( IF 6.8 ) Pub Date : 2020-07-23 , DOI: 10.1016/j.gendis.2020.07.010
Xuejing Yu 1 , Dongchuan Ran 2 , Jinhui Wang 3 , Yuan Qin 2 , Ruishan Liu 3 , Xueli Shi 3 , Yiping Wang 3 , Chang Xie 3 , Jia Jiang 3 , Jianzhong Zhou 3
Affiliation  

Superspreaders are critical infectious resources in multiple infectious diseases. They can be asymptomatic or present mild symptoms but can transmit pathogens to susceptible populations, leading to severe symptoms, and even death. Early identification of this population is extremely important to inhibit the spread of infectious diseases. Right now, the whole global world is suffering from a devastating infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this article, a superspreader cluster event in coronavirus disease 2019 (COVID-19) was identified by tracking contacting histories of infected patients. This cluster was found to be originated from an asymptomatic SARS-CoV-2 carrier, which resulted in 13 secondary cases getting infected. All the secondary patients presented with non-typical symptoms of COVID-19, such as fever, dry cough, and myalgia, one of which died of respiratory failure at the end. From this cluster, we learn that people with older ages, low immunity, multiple underlying diseases, especially pulmonary diseases, can contribute to a poor prognosis. Thus, asymptomatic superspreaders of COVID-19 can be extremely dangerous and must be handled time-efficiently.



中文翻译:

尚不清楚但存在危险:无症状的SARS-CoV-2携带者。

超级传播者是多种传染病中的关键传染资源。它们可能无症状或表现出轻微症状,但可以将病原体传播到易感人群,导致严重症状,甚至死亡。对该人群的早期识别对于抑制传染病的传播极为重要。目前,整个全球正遭受由严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)引起的毁灭性传染病。在本文中,通过跟踪感染患者的接触史确定了2019年冠状病毒病(COVID-19)中的超级扩散簇事件。发现该簇源于无症状的SARS-CoV-2携带者,导致13例继发病例被感染。所有继发患者均表现出COVID-19的非典型症状,例如发烧,干咳和肌痛,其中之一死于呼吸衰竭。从这个群体中,我们了解到年龄较大,免疫力低下,多种潜在疾病(尤其是肺部疾病)的人可能会导致不良的预后。因此,无症状的COVID-19超级撒播药可能非常危险,必须高效处理。

更新日期:2020-07-23
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