Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications. Among them, N6-methyladenosine (m6A), which has been shown to play key roles in RNA splicing, stability, nuclear export, and translation, is the most abundant modification of RNA. Extensive studies of m6A modification of mRNAs have been carried out, while little is known about m6A modification of long non-coding RNAs (lncRNAs). Recently, several studies reported m6A modification of lncRNAs. In this review, we focus on these m6A-modified lncRNAs and discuss possible functions of m6A modification.

中文翻译：

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N6-甲基腺苷修饰在lncRNA中的功能

越来越多的证据表明，mRNA通常会进行转录后修饰。其中，N6-甲基腺苷（m6A）已被证明在RNA剪接，稳定性，核输出和翻译中起着关键作用，是对RNA的最丰富的修饰。已经对mRNA的m6A修饰进行了广泛的研究，而对长非编码RNA（lncRNA）的m6A修饰知之甚少。最近，一些研究报道了lncRNA的m6A修饰。在这篇综述中，我们专注于这些m6A修饰的lncRNA，并讨论了m6A修饰的可能功能。