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Cell-free reactions in continuous manufacturing systems
Current Opinion in Green and Sustainable Chemistry ( IF 9.3 ) Pub Date : 2020-07-03 , DOI: 10.1016/j.cogsc.2020.100380
Yan Chen , Ali Emileh , Nicholas Brideau , Joshua Britton

Cell-free enzymatic transformations can overcome some of the limitations of whole-cell biocatalysis. While flow chemistry has matured into an established discipline in organic synthesis, its use in cell-free biocatalysis is just beginning to be explored. Here, we review examples of recent advancements between 2018 and 2020. We particularly focus on enzyme immobilization and cofactor recycling as these are two major research focuses in this field. This review also provides perspective on future directions.



中文翻译:

连续生产系统中的无细胞反应

无细胞的酶促转化可以克服全细胞生物催化的某些局限性。尽管流化学已发展成为有机合成的既定学科,但其在无细胞生物催化中的用途才刚刚开始探索。在此,我们回顾一下2018年至2020年之间最新进展的示例。我们特别关注酶固定化和辅因子回收,因为这是该领域的两个主要研究重点。这篇评论还提供了未来方向的观点。

更新日期:2020-07-03
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