In the previous literature, no clear conclusions have been reached about the effect of gender differences on research performance (RP) in science, as measured by publication productivity, number of citations, and academic awards. Meanwhile, a gap also exists in the research regarding gender differences in international academic collaboration. To complement the existing literature, this study investigated the achievements of scientists engaged in international academic collaboration, which places heavy demands on language and communication skills and in which female scientists appear to have more advantages than male scientists. We investigated the effect of international collaboration carried out by chemists from China’s Project 985 universities and the Chinese Academy of Sciences and compared the extent to which the international collaboration improved female and male scientists’ academic performance. The results indicated that, compared to male scientists, female scientists performed better and significantly improved their academic performance through international collaboration. This conclusion was valid for different periods throughout chemists’ academic careers. The policy implications are discussed at the end of this study.