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The role of interictal discharges in ictogenesis — A dynamical perspective
Epilepsy & Behavior ( IF 2.6 ) Pub Date : 2019-12-01 , DOI: 10.1016/j.yebeh.2019.106591
Jan Chvojka 1 , Jan Kudlacek 1 , Wei-Chih Chang 2 , Ondrej Novak 3 , Filip Tomaska 3 , Jakub Otahal 4 , John G R Jefferys 5 , Premysl Jiruska 6
Affiliation  

Interictal epileptiform discharge (IED) is a traditional hallmark of epileptic tissue that is generated by the synchronous activity of a population of neurons. Interictal epileptiform discharges represent a heterogeneous group of pathological activities that differ in shape, duration, spatiotemporal distribution, underlying cellular and network mechanisms, and their relationship to seizure genesis. The exact role of IEDs in epilepsy is still not well understood, and there remains a persistent dichotomy about the impact on IEDs on seizures. Proseizure, antiseizure, and no impact on ictogenesis have all been described in previous studies. In this article, we review the existing knowledge on the role of interictal discharges in seizure genesis, and we discuss how dynamical approaches to ictogenesis can explain the existing dichotomy about the multifaceted role of IEDs in ictogenesis. This article is part of the Special Issue "NEWroscience 2018".

中文翻译:

发作间期放电在 ictogenesis 中的作用——动力学视角

发作间期癫痫样放电 (IED) 是癫痫组织的传统标志,由一组神经元的同步活动产生。发作间期癫痫样放电代表了一组异质的病理活动,它们的形状、持续时间、时空分布、潜在的细胞和网络机制以及它们与癫痫发作的关系不同。IED 在癫痫中的确切作用仍不清楚,关于 IED 对癫痫发作的影响仍然存在持续的二分法。先前的研究中都描述了 Proseizure、antiseizure 和对 ictogenesis 的无影响。在本文中,我们回顾了关于发作间期放电在癫痫发作发生中的作用的现有知识,我们讨论了 ictogenesis 的动态方法如何解释现有的关于 IED 在 ictogenesis 中的多方面作用的二分法。本文是特刊“NEWroscience 2018”的一部分。
更新日期:2019-12-01
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