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Anticancer Drug Delivery Systems Based on Curcumin Nanostructures: A Review
Pharmaceutical Chemistry Journal ( IF 0.9 ) Pub Date : 2020-07-01 , DOI: 10.1007/s11094-020-02203-0
Zahra Mirzaie , Mohammad Barati , Mohammad Asadi Tokmedash

In recent years, the application of nanostructures in biomedical and pharmaceutical fields has increased. The special designs and compositions make nanocomposites very useful alternatives to conventional materials. Curcumin is a promising anti-cancer agent that has a positive and significant effect on chemotherapeutic achievements. The anticancer properties of curcumin have been widely investigated in different forms such as nanoparticles and nanocomposite structures. Chitosan-based nanocomposites, magnetic nanoparticles, polymer nanocomposites and blends, and montmorillonite- and alginate-based nanocomposites have been used in loading curcumin for various purposes. The anticancer preparations of curcumin nanoparticles and drug release systems employing curcumin-loaded nanoparticles, electrospun nanofibers, and hydrogel nanocomposites have been investigated. This review provides a summary of the applications of nanostructures containing curcumin, especially in controlled drug release systems. The curcumin nanoparticles and nanocomposites are suitable candidates for anticancer applications. On the nano-scale, curcumin has better aqueous solubility and, if used in a nanocomposite, there is a good ability for manipulating the drug delivery system properties.

中文翻译:

基于姜黄素纳米结构的抗癌药物递送系统:综述

近年来,纳米结构在生物医学和制药领域的应用越来越多。特殊的设计和成分使纳米复合材料非常有用,可以替代传统材料。姜黄素是一种很有前途的抗癌剂,对化疗成果具有积极而显着的影响。姜黄素的抗癌特性以不同的形式被广泛研究,如纳米颗粒和纳米复合结构。基于壳聚糖的纳米复合材料、磁性纳米颗粒、聚合物纳米复合材料和混合物,以及基于蒙脱石和藻酸盐的纳米复合材料已被用于负载姜黄素,用于各种目的。姜黄素纳米颗粒的抗癌制剂和采用姜黄素纳米颗粒、电纺纳米纤维、和水凝胶纳米复合材料进行了研究。本综述总结了含有姜黄素的纳米结构的应用,特别是在控释系统中的应用。姜黄素纳米颗粒和纳米复合材料是抗癌应用的合适候选者。在纳米尺度上,姜黄素具有更好的水溶性,如果用于纳米复合材料,则具有良好的操纵药物递送系统特性的能力。
更新日期:2020-07-01
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