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Development of molecularly imprinted magnetic iron oxide nanoparticles for doxorubicin drug delivery
Monatshefte für Chemie - Chemical Monthly ( IF 1.8 ) Pub Date : 2020-06-26 , DOI: 10.1007/s00706-020-02644-z
Sayed Tayyab Raza Naqvi , Tahir Rasheed , Dilshad Hussain , Saadat Majeed , Batool Fatima , Muhammad Najam ul Haq , Ayesha Zarin , Rahat Nawaz

Abstract

In this study, we prepare a biocompatible and magnetic material coated with dopamine (Fe3O4/SiO2@DA) for drug delivery of doxorubicin. Doxorubicin is a commercially available drug for the treatment of several types of cancers such as metastatic breast carcinoma, blood, lungs, ovarian carcinoma, and sarcoma. Magnetic nanoparticles are synthesized by co-precipitation method and coated with dopamine. Characterization of materials is carried out by Fourier transform infrared spectroscopy, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. Magnetic properties of the particles are evaluated by magnetic moment measurements. Later, this material is applied to the targeted delivery of doxorubicin. Several experimental parameters such as loading time, release time, loading temperature, release temperature, desorption pH, amount of nanomaterial, salt concentration, and effect of solvent are optimized. Loading of a drug is maximum in basic pH while acidic pH (3.3) works best for the desorption process. With increasing the amount of material, loading of drug increase. Moreover, salt (NaCl) concentration does not affect the loading process. Loading of a drug is maximum at a lower temperature (room temperature) while the release is more efficient at a higher temperature (40–45 °C). This material showed superior efficiency (drug loading, drug release, and time) as compared to previously reported similar materials. These results indicate that Fe3O4/SiO2@DA has excellent potential to carry the drug and deliver to cancerous cells which have acidic pH and higher temperature as compared to normal healthy cells.

Graphic abstract



中文翻译:

阿霉素药物分子印迹磁性氧化铁纳米粒子的开发

摘要

在这项研究中,我们准备了一种多巴胺(Fe 3 O 4 / SiO 2@DA)用于阿霉素的药物递送。阿霉素是可商购的药物,用于治疗几种类型的癌症,例如转移性乳腺癌,血液癌,肺癌,卵巢癌和肉瘤。磁性纳米粒子通过共沉淀法合成,并用多巴胺包被。材料的表征通过傅立叶变换红外光谱,扫描电子显微镜和能量色散X射线光谱进行。通过磁矩测量来评估颗粒的磁性。后来,这种材料被应用于阿霉素的靶向递送。优化了几个实验参数,例如加载时间,释放时间,加载温度,释放温度,解吸pH,纳米材料的量,盐浓度和溶剂效果。在碱性pH中,药物的负载量最大,而酸性pH(3.3)最适合解吸过程。随着材料量的增加,药物的负荷增加。此外,盐(NaCl)的浓度不会影响加载过程。在较低的温度(室温)下,药物的负载量最大,而在较高的温度(40–45°C)下释放效率更高。与以前报道的类似材料相比,这种材料显示出了更高的效率(载药量,药物释放和时间)。这些结果表明铁 在较低的温度(室温)下,药物的负载量最大,而在较高的温度(40–45°C)下释放效率更高。与先前报道的类似材料相比,这种材料显示出了更高的效率(载药量,药物释放和时间)。这些结果表明铁 在较低温度(室温)下,药物的负载量最大,而在较高温度(40–45°C)下,释放效率更高。与以前报道的类似材料相比,这种材料显示出了更高的效率(载药量,药物释放和时间)。这些结果表明铁与正常的健康细胞相比,3 O 4 / SiO 2 @DA具有极好的潜力来携带药物并将其传递至具有酸性pH和较高温度的癌细胞。

图形摘要

更新日期:2020-06-26
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