Paper devices have recently attracted considerable attention as a class of cost-effective cell culture substrates for various biomedical applications. The paper biomaterial can be used to partially mimic the in vivo cell microenvironments mainly due to its natural three-dimensional characteristic. The paper-based devices provide precise control over their structures as well as cell distributions, allowing recapitulation of certain interactions between the cells and the extracellular matrix. These features have shown great potential for the development of normal and diseased human tissue models. In this review, we discuss the fabrication of paper-based devices for in vitro tissue modeling, as well as the applications of these devices toward drug screening and personalized medicine. It is believed that paper as a biomaterial will play an essential role in the field of tissue model engineering due to its unique performances, such as good biocompatibility, eco-friendliness, cost-effectiveness, and amenability to various biodesign and manufacturing needs.

中文翻译：

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用于体外组织建模的纸基设备的制造

作为用于各种生物医学应用的一类具有成本效益的细胞培养基质，纸装置最近引起了相当大的关注。纸生物材料主要由于其天然的三维特征而可用于部分模拟体内细胞微环境。基于纸张的设备可精确控制其结构以及细胞分布，从而概括了细胞与细胞外基质之间的某些相互作用。这些特征显示出开发正常和患病的人体组织模型的巨大潜力。在这篇综述中，我们讨论了用于体外组织建模的纸质设备的制造，以及这些设备在药物筛选和个性化医学中的应用。