A new family of polyphenolic carbosilane dendrimers functionalized with ferulic, caffeic, and gallic acids has been obtained through a straightforward amidation reaction. Their antioxidant activity has been studied by different techniques such as DPPH (2,2′-diphenyl-1-picrylhydrazyl) radical scavenging assay, FRAP assay (ferric reducing antioxidant power), and cyclic voltammetry. The antioxidant analysis showed that polyphenolic dendrimers exhibited higher activities than free polyphenols in all cases. The first-generation dendrimer decorated with gallic acid stood out as the best antioxidant compound, displaying a correlation between the number of hydroxyl groups in the polyphenol structure and the antioxidant activity of the compounds. Moreover, the antibacterial capacity of these new systems has been screened against Gram-positive (+) and Gram-negative (−) bacteria, and we observed that polyphenolic dendrimers functionalized with caffeic and gallic acids were capable of decreasing bacterial growth. In contrast, ferulic carbosilane dendrimers and free polyphenols showed no effect, establishing a correlation between antioxidant activity and antibacterial capacity. Finally, a viability assay in human skin fibroblasts cells (HFF-1) allowed for corroborating the nontoxicity of the polyphenolic dendrimers at their active antibacterial concentration.

中文翻译：

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用多酚部分官能化的碳硅烷树枝状聚合物的抗氧化和抗菌性能。

通过直接的酰胺化反应，已经获得了用阿魏酸，咖啡酸和没食子酸官能化的多酚碳硅烷树状聚合物的新家族。他们的抗氧化活性已经通过不同的技术进行了研究，例如DPPH（2,2'-二苯基-1-picylhydrazyl）自由基清除测定，FRAP测定（三价铁还原抗氧化能力）和循环伏安法。抗氧化剂分析表明，在所有情况下，多酚树枝状聚合物均比游离多酚具有更高的活性。装饰有没食子酸的第一代树状聚合物是最好的抗氧化剂化合物，显示了多酚结构中羟基的数量与化合物的抗氧化剂活性之间的相关性。此外，这些新系统的抗菌能力已经针对革兰氏阳性（+）和革兰氏阴性（-）细菌进行了筛选，我们观察到，用咖啡酸和没食子酸官能化的多酚树枝状聚合物能够减少细菌的生长。相反，阿魏碳硅烷树状大分子和游离多酚没有作用，在抗氧化活性和抗菌能力之间建立了联系。最后，在人皮肤成纤维细胞（HFF-1）中进行的活力测定证实了多酚树状聚合物在其活性抗菌浓度下的无毒性。建立抗氧化活性和抗菌能力之间的关系。最后，在人皮肤成纤维细胞（HFF-1）中进行的活力测定证实了多酚树状聚合物在其活性抗菌浓度下的无毒性。建立抗氧化活性和抗菌能力之间的关系。最后，在人皮肤成纤维细胞（HFF-1）中进行的活力测定证实了多酚树状聚合物在其活性抗菌浓度下的无毒性。