当前位置: X-MOL 学术Acta Physiol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
NaV 1.5 in embryonic heart development.
Acta Physiologica ( IF 6.3 ) Pub Date : 2020-07-23 , DOI: 10.1111/apha.13542
Eric Cortada 1, 2 , Marcel Verges 1, 2, 3
Affiliation  

The voltage‐gated sodium (NaV) channel is essential for cardiomyocyte function. It is responsible for generating the rising phase of the cardiac action potential. The channel consists of a pore‐forming, α‐subunit, whose main cardiac isoform is NaV1.5, and one or two associated β‐subunits. Moreover, it is part of a macromolecular complex including a diverse set of interacting proteins, some of which are implicated in regulating its localization to specialized membrane domains of the cardiomyocyte sarcolemma.

中文翻译:

NaV 1.5在胚胎心脏发育中。

电压门控钠(Na V)通道对于心肌细胞功能至关重要。它负责产生心脏动作电位的上升阶段。该通道由成孔的α亚基(其主要心脏亚型为Na V 1.5)和一个或两个相关的β亚基组成。此外,它是大分子复合物的一部分,包括多种相互作用的蛋白质,其中一些涉及调节其定位于心肌肉瘤的特定膜结构域。
更新日期:2020-07-24
down
wechat
bug