The macrophage migration inhibiting factor (MIF) is a protein that promotes the activation of immune cells and the production of other proinflammatory cytokines such as TNF‐α, IL‐1β, and IFN‐γ, which have proposed to play an essential role in the pathogenesis of vitiligo. The study aimed to assess the association between MIF polymorphisms (−794 CATT_5‐8 and −173 G>C), MIF in situ expression, and MIF serum concentrations with susceptibility and disease activity in patients with non‐segmental vitiligo (NSV) from western Mexico.

中文翻译：

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巨噬细胞抑制因子（MIF）基因多态性与疾病易感性以及墨西哥西部患者活动性非节段性白癜风中循环MIF水平相关。

巨噬细胞迁移抑制因子（MIF）是一种蛋白质，可促进免疫细胞的活化和其他促炎性细胞因子（如TNF-α，IL-1β和IFN-γ）的产生，这些物质已被证明在巨噬细胞迁移中起重要作用。白癜风的发病机理。这项研究旨在评估MIF多态性（−794 CATT _5-8和-173 G> C），MIF原位表达和MIF血清浓度与非段性白癜风（NSV）患者的易感性和疾病活动之间的关系墨西哥西部。