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C,N-chelated diaminocarbene platinum(II) complexes derived from 3,4-diaryl-1H-pyrrol-2,5-diimines and cis-dichlorobis(isonitrile)platinum(II): Synthesis, cytotoxicity, and catalytic activity in hydrosilylation reactions
Journal of Organometallic Chemistry ( IF 2.3 ) Pub Date : 2020-07-24 , DOI: 10.1016/j.jorganchem.2020.121435
Anastasiia M. Afanasenko , Tatiana G. Chulkova , Irina A. Boyarskaya , Regina M. Islamova , Anton A. Legin , Bernhard K. Keppler , Stanislav I. Selivanov , Anatoly N. Vereshchagin , Michail N. Elinson , Matti Haukka

The reaction of 3,4-diaryl-1H-pyrrol-2,5-diimines with cis-dichlorobis(isonitrile)platinum(II) affords the C,N-chelated diaminocarbene platinum(II) complexes, which have been fully characterized including molecular spectroscopy, single crystal X-ray diffraction and DFT calculations. The obtained platinum(II) complexes are effective catalysts for the hydrosilylation of alkynes and alkenes. Thus, the reaction of phenylacetylene with triethoxysilane leads to the formation of α- and β-(E)-vinylsilanes, generating TON’s in the range of 103 to 104 and TOF’s in the range of 102 to 103 h−1. Also, the cross-linked silicones, possessing the luminescence properties, were obtained by the hydrosilylation reaction of vinyl- and hydride-containing polysiloxanes. Additionally, the efficiency of diaminocarbene platinum(II) complexes against CH1/PA-1, SW480, and A549 cancer cell lines has been demonstrated by in vitro cytotoxicity studies.



中文翻译:

由3,4-二芳基-1H-吡咯-2,5-二亚胺和顺二氯双(异腈)铂(II)衍生的C,N螯合的二氨基碳烯铂(II)配合物:氢化硅烷化反应的合成,细胞毒性和催化活性

3,4-二芳基-1 H-吡咯-2,5-二亚胺与-二氯双(异腈)铂(II)的反应可得到C,N-螯合的二氨基碳烯铂(II)络合物,其特征包括分子光谱,单晶X射线衍射和DFT计算。所得的铂(II)配合物是炔烃和烯烃的氢化硅烷化的有效催化剂。因此,苯乙炔与三乙氧基硅烷的反应导致形成α-和β-(E)-乙烯基硅烷,从而产生的TON范围为10 3至10 4,TOF范围为10 2至10 3 h -1。而且,通过含乙烯基和氢化物的聚硅氧烷的氢化硅烷化反应获得具有发光性能的交联的有机硅。另外,通过体外细胞毒性研究证明了二氨基碳烯铂(II)配合物对抗CH1 / PA-1,SW480和A549癌细胞系的效率。

更新日期:2020-07-31
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