Introduction

Contrary to the production of oxidant and inflammation biomarkers, antioxidant enzymes decrease with age and the adaptive response to oxidative stress is reduced. The effects of the different resistance exercise protocols to attenuate these conditions are largely unexplored.

Objective

We compared the acute effects of traditional resistance exercise (TRE) and high velocity RE (HVRE) on inflammatory biomarkers and antioxidant activity in elderly women.

Methods

Fourteen elderly women (67 ± 7 years) were randomly assigned to TRE or HVRE. Blood samples were collected to measure inflammatory markers and antioxidant enzymes at three time-points (pre-exercise, post-exercise, 30 min post-exercise).

Results

TRE and HVRE induced acute reductions over time on tumor necrosis factor-alpha, interleukin-6 (IL-6), soluble receptor of IL-6 (sIL-6R), as well in catalase, glutathione and superoxide dismutase antioxidant levels without differences between groups. In addition, TRE and HVRE groups displayed acute increments in interleukin-10 (IL-10) and IL-10/IL-6 ratio over time, while the HVRE protocol displayed higher IL-10 values post-exercise and 30 min post-exercise time points as compared with TRE. Based on magnitude based inference, subjects from the HVRE group demonstrated superior responsiveness for IL-6 and IL-10 as compared with the TRE group. All participants from the HVRE group displayed a minimal clinical important difference on IL-10 levels as compared to only two persons from the TRE group.

Conclusion

Both RE protocols were capable of positive changes in inflammatory and antioxidant status in elderly subjects, but HVRE demonstrated a superior response on IL-10. The HVRE may be incorporated to exercise recommendation in this population.

中文翻译：

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高速和传统抵抗运动对老年女性血清抗氧化剂和炎症生物标志物的影响：一项随机交叉试验。

介绍

与氧化剂和炎症生物标志物的产生相反，抗氧化剂随着年龄的增长而减少，并且对氧化应激的适应性反应也减少了。在很大程度上尚未探索不同的抵抗运动方案对减轻这些状况的影响。

目的

我们比较了传统抵抗运动（TRE）和高速RE（HVRE）对老年女性炎症生物标志物和抗氧化活性的急性影响。

方法

14名老年妇女（67±7岁）被随机分配到TRE或HVRE。在三个时间点（运动前，运动后，运动后30分钟）收集血样以测量炎性标志物和抗氧化酶。

结果

随着时间的推移，TRE和HVRE导致肿瘤坏死因子-α，白介素6（IL-6），IL-6的可溶性受体（sIL-6R）以及过氧化氢酶，谷胱甘肽和超氧化物歧化酶抗氧化剂水平的急性降低，两者之间没有差异组。此外，TRE和HVRE组显示白介素10（IL-10）和IL-10 / IL-6比值随时间急剧增加，而HVRE方案在运动后和运动后30分钟显示出更高的IL-10值与TRE相比的时间点。基于大小的推论，HVRE组的受试者对IL-6和IL-10的反应性优于TRE组。与仅有TRE组的两个人相比，HVRE组的所有参与者在IL-10水平上显示出最小的临床重要差异。

结论

两种RE方案​​均能使老年受试者的炎症和抗氧化剂状态发生积极变化，但HVRE对IL-10表现出更好的反应。可以将HVRE纳入该人群中以进行推荐。