An array of previously synthesized 4-methyl-7-amino and amido coumarins 4a–u has been screened for their antimicrobial and antioxidant properties. Some of the compounds exhibited promising antibacterial and antifungal activities (MIC ranging from 4–64 μg/mL) when compared to the respective standards. Compound 4u showed comparable antibacterial activity with the standard, ciprofloxacin, whereas compounds 4u and 4t displayed promising antifungal activity when compared to the standard, fluconazole. The in silico docking studies against gyrase enzyme revealed the fact that 4u possessed hydrogen bonding and significant hydrophobic interactions, which may be the reason for its superior antibacterial activity as compared to the other compounds. Compounds 4c and 4m showed comparable antioxidant activity with the standard, BHT, which can be attributed to the presence of electron-donating substituents.

中文翻译：

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4-甲基-7-氨基/酰胺香豆素衍生物作为潜在的抗菌剂和抗氧化剂

一系列先前合成的 4-甲基-7-氨基和酰胺基香豆素 4a-u 已被筛选出具有抗菌和抗氧化特性。与各自的标准相比，一些化合物表现出有希望的抗菌和抗真菌活性（MIC 范围为 4-64 μg/mL）。化合物 4u 显示出与标准品环丙沙星相当的抗菌活性，而与标准品氟康唑相比，化合物 4u 和 4t 显示出有希望的抗真菌活性。针对促旋酶的计算机对接研究表明，4u 具有氢键和显着​​的疏水相互作用，这可能是其抗菌活性优于其他化合物的原因。化合物 4c 和 4m 显示出与标准品 BHT 相当的抗氧化活性，