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Positive Selection and Gene Expression Analyses from Salivary Glands Reveal Discrete Adaptations within the Ecologically Diverse Bat Family Phyllostomidae.
Genome Biology and Evolution ( IF 3.3 ) Pub Date : 2020-07-22 , DOI: 10.1093/gbe/evaa151
Michael W Vandewege 1 , Cibele G Sotero-Caio 1 , Caleb D Phillips 1
Affiliation  

The leaf-nosed bats (Phyllostomidae) are outliers among chiropterans with respect to the unusually high diversity of dietary strategies within the family. Salivary glands, owing to their functions and high ultrastructural variability among lineages, are proposed to have played an important role during the phyllostomid radiation. To identify genes underlying salivary gland functional diversification, we sequenced submandibular gland transcriptomes from phyllostomid species representative of divergent dietary strategies. From the assembled transcriptomes, we performed an array of selection tests and gene expression analyses to identify signatures of adaptation. Overall, we identified an enrichment of immunity-related gene ontology terms among 53 genes evolving under positive selection. Lineage-specific selection tests revealed several endomembrane system genes under selection in the vampire bat. Many genes that respond to insulin were under selection and differentially expressed genes pointed to modifications of amino acid synthesis pathways in plant-visitors. Results indicate salivary glands have diversified in various ways across a functional diverse clade of mammals in response to niche specializations.

中文翻译:

唾液腺的阳性选择和基因表达分析揭示了在生态上多样化的蝙蝠科毛鳞科内的离散适应。

就家庭中不同的饮食策略而言,叶鼻蝙蝠(Phyllostomidae)在手翅类中是离群的。唾液腺由于其功能和血统之间的超微结构变异性高而被提议在叶状酰胺辐射中起重要作用。为了鉴定唾液腺功能多样化的基础基因,我们从代表不同饮食策略的phyllostomid物种测序了颌下腺转录组。从组装的转录组中,我们进行了一系列选择测试和基因表达分析,以识别适应性特征。总体而言,我们确定了在正选择下进化的53个基因中与免疫相关的基因本体术语的丰富性。特定于血统的选择测试揭示了吸血蝙蝠中正在选择的几个内膜系统基因。许多对胰岛素有反应的基因处于选择状态,差异表达的基因指出了植物访客中氨基酸合成途径的修饰。结果表明,针对利基市场的专业化,唾液腺在哺乳动物功能多样的进化枝中以各种方式多样化。
更新日期:2020-09-20
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