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WellExplorer: an integrative resource linking hydraulic fracturing chemicals with hormonal pathways and geographic location.
Database: The Journal of Biological Databases and Curation ( IF 5.8 ) Pub Date : 2020-07-23 , DOI: 10.1093/database/baaa053
Owen Wetherbee 1 , Jessica R Meeker 1, 2 , Caroline DeVoto 1 , Trevor M Penning 2, 3 , Jason H Moore 1, 4 , Mary Regina Boland 1, 5
Affiliation  

Exposure to hydraulic fracturing fluid in drinking water increases the risk of many adverse health outcomes. Unfortunately, most individuals and researchers are unaware of the health risks posed by a particular well due to the diversity of chemical ingredients used across sites. We constructed WellExplorer (http://WellExplorer.org), an interactive tool for researchers and community members to use for retrieving information regarding the hormonal, testosterone and estrogen modulators located at each well. We found that wells in Alabama use a disproportionately high number of ingredients targeting estrogen pathways, while Illinois, Ohio and Pennsylvania use a disproportionately high number of ingredients targeting testosterone pathways. Researchers can utilize WellExplorer to study health outcomes related to exposure to fracturing chemicals in their population-based cohorts. Community members can use this resource to search their home or work locations (e.g. town or zip code) to determine proximity between where they live or work and specific hormonal exposures.

中文翻译:

WellExplorer:将水力压裂化学品与激素途径和地理位置联系在一起的综合资源。

饮用水中水力压裂液的接触会增加许多不利健康后果的风险。不幸的是,由于各个站点使用的化学成分的多样性,大多数个人和研究人员并未意识到特定井的健康风险。我们构建了WellExplorer(http://WellExplorer.org),这是一个供研究人员和社区成员使用的交互式工具,用于检索有关每个孔中的激素,睾丸激素和雌激素调节剂的信息。我们发现,阿拉巴马州的水井使用大量成分靶向雌激素途径,而伊利诺伊州,俄亥俄州和宾夕法尼亚州则使用过多成分靶向睾丸激素途径。研究人员可以利用WellExplorer在其基于人群的队列中研究与暴露于压裂化学品有关的健康结果。社区成员可以使用此资源搜索其家庭或工作地点(例如城镇或邮政编码),以确定他们的生活或工作地点与特定的激素暴露之间的接近程度。
更新日期:2020-07-23
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